Pasquali Jean-Louis, Soulas-Sprauel Pauline, Korganow Anne-Sophie, Martin Thierry
Laboratory of Immunopathology, INSERM U 737 and Université Louis Pasteur, Hopitaux Universitaires de Strasbourg, 67 091 Strasbourg, France.
J Autoimmun. 2007 Dec;29(4):250-6. doi: 10.1016/j.jaut.2007.07.006. Epub 2007 Sep 12.
In order to understand how the natural occurrence of autoreactive B cells is controlled in normal individuals, and how self reactive B cells can escape this control during diverse clinical situations, many different transgenic mice have been generated expressing self reactive antibodies. In this review, we focus our attention on disease-associated self reactive transgenic models which show the variety of the tolerization mechanisms. The same transgenic lines are also used to analyse the effects of the autoimmune genetic background on the self reactive B cell fate, as well as to study the influence of infectious agents on the behaviour of the auto-reactive transgenic B cells.
为了了解正常个体中自身反应性B细胞的自然发生是如何被控制的，以及自身反应性B细胞在不同临床情况下如何逃避这种控制，人们已经构建了许多表达自身反应性抗体的不同转基因小鼠。在这篇综述中，我们将注意力集中在与疾病相关的自身反应性转基因模型上，这些模型展示了多种耐受机制。同样的转基因品系也被用于分析自身免疫遗传背景对自身反应性B细胞命运的影响，以及研究感染因子对自身反应性转基因B细胞行为的影响。
