Lokiec François, Lansiaux Amélie
Service de Pharmacologie, Centre René Huguenin, 35, rue Dailly, 92210 Saint-Cloud.
Bull Cancer. 2007;94 Spec No Actualites:S85-9.
Gemcitabine or Gemzar forms part of the class of the anti-cancer drugs antimetabolites. Gemcitabine is a structural analogue of the deoxycytidine with 2 fluorine atoms. There is a strong analogy between gemcitabine and cytosine arabinoside (Aracytine or Depocyt), at the same time structural, mechanistic and metabolic. However, if the intracellular derivatives triphosphate of gemcitabine seem more stable than those of the cytarabine, the two molecules move away from share their therapeutic activity. Indeed, if the cytosine arabinoside finds its place in the treatment of hematologic diseases, myeloblastic or lymphoblastic acute leukaemia and in acute myeloid leukaemias and myelodysplasy, gemcitabine sees its indications in the treatment of solid tumours such as non small cell lung cancer, adenocarcinoma of the pancreas, cancer of the bladder and metastatic breast cancer.
吉西他滨（或健择）是抗癌药物抗代谢物类别的一部分。吉西他滨是一种带有2个氟原子的脱氧胞苷的结构类似物。吉西他滨与阿糖胞苷（阿糖胞嘧啶或Depocyt）在结构、机制和代谢方面存在很强的相似性。然而，如果吉西他滨的细胞内三磷酸衍生物似乎比阿糖胞苷的更稳定，那么这两种分子在治疗活性方面就有所不同。的确，如果阿糖胞苷在血液系统疾病、急性髓细胞性或淋巴细胞性白血病以及急性髓性白血病和骨髓发育异常的治疗中占有一席之地，那么吉西他滨则用于实体瘤的治疗，如非小细胞肺癌、胰腺癌、膀胱癌和转移性乳腺癌。
