Mollenauer S, Bryson R, Speck C, Chamberlin J R
Department of Psychology, San Diego State University, CA 92182-0350.
Pharmacol Biochem Behav. 1991 Jul;39(3):821-4. doi: 10.1016/0091-3057(91)90173-y.
C57BL/6J mice were given five weeks of voluntary wheel running and then studied for behavioral impairment after an intoxicating dose of ethanol. Forty-four mice, 22 males and 22 females, were assigned to Wheel (free access to a running wheel in the home cage) or No Wheel conditions. At the end of the training period, animals were removed from the exercise cages and tested for noise avoidance after 2.4 g/kg ethanol (EtOH) or physiological saline (Sal). Mice could avoid 87.5-dB noise by entering and remaining in a randomly designated "safe corner." In unexercised animals, EtOH caused a strong suppression of locomotor activity and avoidance behavior: No Wheel EtOH mice differed significantly from No Wheel Sal mice on both measures. In exercised animals, EtOH failed to cause significant suppression: Wheel EtOH animals did not differ significantly from Wheel Sal animals on either measure. The present results suggest that prior exercise training may be effective in offsetting the effects of acute ethanol intoxication.
C57BL/6J小鼠进行了为期五周的自主轮转跑步，然后在给予致醉剂量的乙醇后研究行为损伤情况。44只小鼠，22只雄性和22只雌性，被分配到轮转组（可在家笼中自由使用转轮）或无轮转组。在训练期结束时，将动物从运动笼中取出，在给予2.4 g/kg乙醇（EtOH）或生理盐水（Sal）后测试其噪音回避能力。小鼠可通过进入并留在随机指定的“安全角落”来回避87.5分贝的噪音。在未运动的动物中，乙醇强烈抑制运动活动和回避行为：无轮转乙醇组小鼠在这两项指标上与无轮转生理盐水组小鼠有显著差异。在运动过的动物中，乙醇未能引起显著抑制：轮转乙醇组动物在任何一项指标上与轮转生理盐水组动物均无显著差异。目前的结果表明，先前的运动训练可能有效地抵消急性乙醇中毒的影响。
