Yilmaz Gulsen, Yilmaz Fatma Meric, Aral Yalcin, Yucel Dogan
Clinical Biochemistry Laboratory, Ankara Education and Research Hospital, Ministry of Health, Ankara, Turkey.
J Clin Lab Anal. 2007;21(5):260-4. doi: 10.1002/jcla.20181.
Cardiovascular disease is a common cause of death for diabetic patients. High sialic acid levels (SA) and increased oxidative stress are important factors for cardiovascular diseases. We aimed to research whether SA and thiobarbituric acid reactive substances (TBARS) levels are associated with the degree of the diabetic regulation and investigate if SA and TBARS levels can be controlled with the regulation of the blood glucose levels. A total of 179 subjects were included in the study. Three groups, which were comprised of subjects with type 2 diabetes mellitus (DM) (DM group [DMG], n=149), impaired glucose tolerance (IGT) (IGT group [IGTG], n=15), and normal oral glucose tolerance (NGT) (NGTgroup [NGTG], n=15) were constituted. Glucose, cholesterol, high-density lipoprotein (HDL) and glycated hemoglobin (HbA1C), SA, and TBARS were measured in the sera of the patients. SA and TBARS levels were significantly increased in subjects with type 2 DM (P<0.001 for both). SA concentrations showed significant correlation with triglycerides (r=0.229; P<0.05), fasting glucose (r=0.508; P<0.01), 2-hr postprandial glucose (r=0.455; P<0.01), and HbA1C (r=0.467; P<0.01), and there was a positive correlation between TBARS and HbA1C (r=0.251; P<0.01). Diabetic patients were found to have higher risk for inflammation and oxidative stress. The regulation of blood glucose levels may contribute to the decline of both SA and TBARS levels.
心血管疾病是糖尿病患者常见的死亡原因。高唾液酸水平（SA）和氧化应激增加是心血管疾病的重要因素。我们旨在研究SA和硫代巴比妥酸反应性物质（TBARS）水平是否与糖尿病的控制程度相关，并调查SA和TBARS水平是否可以通过血糖水平的调节得到控制。共有179名受试者纳入本研究。研究对象分为三组，分别为2型糖尿病（DM）患者（DM组[DMG]，n = 149）、糖耐量受损（IGT）患者（IGT组[IGTG]，n = 15）和口服葡萄糖耐量正常（NGT）者（NGT组[NGTG]，n = 15）。检测了患者血清中的葡萄糖、胆固醇、高密度脂蛋白（HDL）、糖化血红蛋白（HbA1C）、SA和TBARS。2型糖尿病患者的SA和TBARS水平显著升高（两者P均<0.001）。SA浓度与甘油三酯（r = 0.229；P<0.05）、空腹血糖（r = 0.508；P<0.01）、餐后2小时血糖（r = 0.455；P<0.01）和HbA1C（r = 0.467；P<0.01）呈显著相关，TBARS与HbA1C之间存在正相关（r = 0.251；P<0.01）。糖尿病患者被发现有更高的炎症和氧化应激风险。血糖水平的调节可能有助于SA和TBARS水平的下降。
