Stepanić Vesna, Matković Visnja, Corusić Ante, Barisić Dubravko, Buković Damir, Ilić-Forko Jadranka
Department of Gynecology and Obstetrics, University Hospital "Zagreb", Zagreb, Croatia.
Coll Antropol. 2007 Jun;31(2):633-6.
Paraneoplastic cerebellar degeneration (PCD), the one of the most common paraneoplastic syndromes, refer to clinical disorders associated mostly with lung, ovarian and breast cancer, but not directly caused by the cancer or its metastases. Pathologic finding is an extensive loss of Purkinje cells in the cerebellum. Immunohistochemically, the auto-antibodies on the Purkinje cells had been detected. Clinically, PCD is characterized by sub-acutely evolving pancerebellar symptoms. Neurological dysfunction may appear before the detection of the underlying cancer. Therefore, the surgical exploration is necessary for the final diagnosis. The patient undergoes specific therapy. Soon, neurological status of the patient gets irreparable worse. Death come usually 2-3 years after the first symptoms of the PCD occurs. Case of a 63-years old woman with PCD as the first evidence of her cancer is reported. The patient developed brain metastases and died almost 3 years after the first symptoms of PCD occur
副肿瘤性小脑变性（PCD）是最常见的副肿瘤综合征之一，指主要与肺癌、卵巢癌和乳腺癌相关的临床病症，但并非由癌症或其转移灶直接引起。病理表现为小脑浦肯野细胞广泛丧失。免疫组化检测发现浦肯野细胞上存在自身抗体。临床上，PCD的特征是亚急性进展的全小脑症状。神经功能障碍可能在潜在癌症被发现之前出现。因此，手术探查对于最终诊断是必要的。患者接受了特定治疗。很快，患者的神经状态变得不可挽回地恶化。通常在PCD首次出现症状后2至3年死亡。报告了一例63岁女性，以PCD作为其癌症的首发证据。该患者出现脑转移，在PCD首次出现症状后近3年死亡 。
