Kumar Bhavna, Cordell Kitrina G, Lee Julia S, Prince Mark E, Tran Huong H, Wolf Gregory T, Urba Susan G, Worden Francis P, Chepeha Douglas B, Teknos Theodoros N, Eisbruch Avraham, Tsien Christina I, Taylor Jeremy M G, D'Silva Nisha J, Yang Kun, Kurnit David M, Bradford Carol R, Carey Thomas E
Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Int J Radiat Oncol Biol Phys. 2007;69(2 Suppl):S109-11. doi: 10.1016/j.ijrobp.2007.05.072.
Induction chemotherapy and concurrent chemoradiation for responders or immediate surgery for non-responders is an effective treatment strategy head and neck squamous cell carcinoma (HNSCC) of the larynx and oropharynx. Biomarkers that predict outcome would be valuable in selecting patients for therapy. In this study, the presence and titer of high risk human papilloma virus (HPV) and expression of epidermal growth factor receptor (EGFR) in pre-treatment biopsies, as well as smoking and gender were examined in oropharynx cancer patients enrolled in an organ sparing trial. HPV16 copy number was positively associated with response to therapy and with overall and disease specific survival, whereas EGFR expression, current or former smoking behavior, and female gender (in this cohort) were associated with poor response and poor survival in multivariate analysis. Smoking cessation and strategies to target EGFR may be useful adjuncts for therapy to improve outcome in the cases with the poorest biomarker profile.
对于喉和口咽的头颈部鳞状细胞癌（HNSCC），诱导化疗及对有反应者进行同步放化疗或对无反应者立即手术是一种有效的治疗策略。预测预后的生物标志物对于选择治疗患者很有价值。在本研究中，对参加器官保留试验的口咽癌患者的治疗前活检组织检测了高危人乳头瘤病毒（HPV）的存在及滴度、表皮生长因子受体（EGFR）的表达，以及吸烟情况和性别。HPV16拷贝数与治疗反应、总生存及疾病特异性生存呈正相关，而在多因素分析中，EGFR表达、当前或既往吸烟行为以及女性性别（在该队列中）与反应差和生存差相关。戒烟及针对EGFR的策略可能是改善生物标志物特征最差病例治疗结局的有用辅助治疗手段。
