Katoh S, Kohno H, Ohkubo Y
Department of Radiopharmacy, Tohoku College of Pharmacy, Sendai, Japan.
Res Commun Chem Pathol Pharmacol. 1991 Aug;73(2):145-52.
The treatment of rat hepatocytes with isoproterenol induced the increase in the affinity of high affinity binding sites and the decrease in the number of low affinity binding sites of epidermal growth factor (EGF). Similar results were obtained from the pretreatment of hepatocytes with cholera toxin. These results suggest that adenylate cyclase affects the affinity and number of EGF-receptor in hepatocytes.
用异丙肾上腺素处理大鼠肝细胞可诱导表皮生长因子（EGF）高亲和力结合位点的亲和力增加以及低亲和力结合位点数量减少。用霍乱毒素预处理肝细胞也得到了类似结果。这些结果表明腺苷酸环化酶影响肝细胞中EGF受体的亲和力和数量。
