Ugazio G, Bosio A, Nebbia C, Soffietti M G
Dipartimento di Medicina e Oncologia Sperimentale, Università di Torino, Italy.
Res Commun Chem Pathol Pharmacol. 1991 Aug;73(2):231-43.
Male and female Wistar rats were administered a diet containing 450 ppm atrazine as early as 60 days prior to the cohabitation period and the same diet was offered to their offspring. Hexobarbital sleeping time and further in vitro assays pointed to a monooxygenase induction which appeared to be more marked in males vs females and most significant in the offspring at weaning. At this age, induction involved also the cytosolic glutathione S-transferase, a phase II enzyme. Results would suggest that the inducing properties of the herbicide can be transferred to the offspring via the placental and/or the mammary route.
早在同居期前60天，就给雄性和雌性Wistar大鼠喂食含450 ppm阿特拉津的日粮，并给它们的后代提供相同的日粮。己巴比妥睡眠时间及进一步的体外试验表明存在单加氧酶诱导现象，这种诱导在雄性大鼠中比雌性大鼠更明显，在断奶时的后代中最为显著。在这个年龄段，诱导还涉及胞质谷胱甘肽S-转移酶，这是一种II期酶。结果表明，除草剂的诱导特性可通过胎盘和/或乳腺途径传递给后代。
