全氟化合物乳剂对丙戊酸与人白蛋白结合的影响。

Perfluorochemical emulsion effect on human albumin binding of valproic acid.

作者信息

Parsons D L, Ravis W R, Huang H C

机构信息

Department of Pharmacal Sciences, School of Pharmacy, Auburn University, AL 36849.

出版信息

Res Commun Chem Pathol Pharmacol. 1991 Aug;73(2):245-8.

PMID:1784838

Abstract

At 37 degrees C, valproic acid was weakly bound by a PFCE through an interaction with the emulsifiers that was independent of both buffer and PFCE concentration. The binding by PFCE was dependent on valproic acid concentration in 0.1 M buffer, but not in 0.2 M buffer. The addition of PFCE to 4% HSA increased the percent free valproic acid due to both HSA dilution and displacement of HSA bound drug. This displacement was apparently due to an interaction with the PFC liquids and/or intact PFCE droplets, and with the oleic acid component of the PFCE.

摘要

在37摄氏度时，丙戊酸通过与乳化剂的相互作用被全氟碳乳剂（PFCE）微弱结合，这种相互作用与缓冲液和PFCE浓度均无关。在0.1 M缓冲液中，PFCE的结合取决于丙戊酸浓度，但在0.2 M缓冲液中则不然。向4%人血清白蛋白（HSA）中添加PFCE会增加游离丙戊酸的百分比，这是由于HSA被稀释以及与HSA结合的药物被置换。这种置换显然是由于与全氟碳液体和/或完整的PFCE液滴以及PFCE的油酸成分发生了相互作用。