Iida K, Ajisaka R, Takeda T, Toyama H, Masuoka T, Sugita Y, Ito I, Ishikawa N
Department of Cardiology, Institute of Clinical Medicine, University of Tsukuba.
Kokyu To Junkan. 1991 Dec;39(12):1227-34.
The effect of aging on cardiac function in patients with right bundle branch block (RBBB) was commonly unknown, so left ventricular function and right ventricular function were investigated, using first-pass radionuclide angiography. Twenty-six patients with RBBB and 28 normal subjects were studied at rest and during bicycle exercise. Patients with RBBB but normal cardiovascular systems aged 33 to 75 years were divided into those within 60 years (n = 17) and those over 65 years (n = 9). Using the same method, normal subjects aged 38 to 83 years were divided into those within 60 years (n = 18) and those over 65 years (n = 10). Mean age between normal subjects and patients with RBBB didn't differ significantly. The response of left ventricular ejection fraction in normal groups rose during exercise, but its exercise tolerance function declined with aging. Left ventricular diastolic filling in normal groups declined at rest and during exercise with aging. Left ventricular function in RBBB groups showed the same results as those of normal groups. The response of right ventricular ejection fraction and its exercise tolerance function in normal groups was not influenced by aging. However, in contrast, right ventricular function in RBBB groups decreased with aging. We suggest that the mechanism of decrease of right ventricular function in aging patients with RBBB may be caused by the change of right ventricular contraction which is affected by the aging process.
右束支传导阻滞（RBBB）患者中衰老对心脏功能的影响通常尚不明确，因此采用首次通过放射性核素血管造影术对左心室功能和右心室功能进行了研究。对26例RBBB患者和28名正常受试者在静息状态和自行车运动期间进行了研究。年龄在33至75岁之间、心血管系统正常的RBBB患者被分为60岁及以下组（n = 17）和65岁以上组（n = 9）。采用相同方法，将年龄在38至83岁之间的正常受试者分为60岁及以下组（n = 18）和65岁以上组（n = 10）。正常受试者和RBBB患者之间的平均年龄无显著差异。正常组左心室射血分数在运动期间升高，但其运动耐量功能随衰老而下降。正常组左心室舒张期充盈在静息状态和运动期间随衰老而下降。RBBB组的左心室功能与正常组结果相同。正常组右心室射血分数的反应及其运动耐量功能不受衰老影响。然而，相比之下，RBBB组的右心室功能随衰老而下降。我们认为，衰老的RBBB患者右心室功能下降的机制可能是由衰老过程影响的右心室收缩变化所致。
