c-Myc利用TRRAP和GCN5来激活RNA聚合酶III转录。
TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription.
作者信息
Kenneth Niall S, Ramsbottom Ben A, Gomez-Roman Natividad, Marshall Lynne, Cole Philip A, White Robert J
机构信息
Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
出版信息
Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14917-22. doi: 10.1073/pnas.0702909104. Epub 2007 Sep 11.
Abstract
Activation of RNA polymerase (pol) II transcription by c-Myc generally involves recruitment of histone acetyltransferases and acetylation of histones H3 and H4. Here, we describe the mechanism used by c-Myc to activate pol III transcription of tRNA and 5S rRNA genes. Within 2 h of its induction, c-Myc appears at these genes along with the histone acetyltransferase GCN5 and the cofactor TRRAP. At the same time, occupancy of the pol III-specific factor TFIIIB increases and histone H3 becomes hyperacetylated, but increased histone H4 acetylation is not detected at these genes. The rapid acetylation of histone H3 and promoter assembly of TFIIIB, c-Myc, GCN5, and TRRAP are followed by recruitment of pol III and transcriptional induction. The selective acetylation of histone H3 distinguishes pol III activation by c-Myc from mechanisms observed in other systems.
摘要
c-Myc对RNA聚合酶（pol）II转录的激活通常涉及组蛋白乙酰转移酶的募集以及组蛋白H3和H4的乙酰化。在此，我们描述了c-Myc用于激活tRNA和5S rRNA基因的pol III转录的机制。在其诱导后2小时内，c-Myc与组蛋白乙酰转移酶GCN5和辅因子TRRAP一起出现在这些基因处。同时，pol III特异性因子TFIIIB的占据增加，组蛋白H3发生高度乙酰化，但在这些基因处未检测到组蛋白H4乙酰化增加。组蛋白H3的快速乙酰化以及TFIIIB、c-Myc、GCN5和TRRAP的启动子组装之后是pol III的募集和转录诱导。组蛋白H3的选择性乙酰化将c-Myc对pol III的激活与其他系统中观察到的机制区分开来。
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