长春瑞滨治疗转移性乳腺癌诱发抗利尿激素分泌异常综合征（SIADH）
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by vinorelbine treatment of metastatic breast cancer.
作者信息
Canzler Ulrich, Schmidt-Göhrich Uta Katharina, Bergmann Sybille, Hänseroth Katrin, Gatzweiler Axel, Distler Wolfgang
机构信息
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus Dresden, Germany.
出版信息
Onkologie. 2007 Sep;30(8-9):455-6. doi: 10.1159/000105143. Epub 2007 Sep 7.
BACKGROUND
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is known as a rare adverse event with chemotherapy. We report the case of a SIADH occurring after vinorelbine treatment.
CASE REPORT
In a 79-year-old woman breast cancer was first diagnosed in 2000. Three years after the first diagnosis the patient developed bone and liver metastases. Seven days after receiving the 1st course of palliative chemotherapy with vinorelbine the patient suffered from decreased mental awareness, fatigue, and physical weakness. After the diagnosis of SIADH based on laboratory findings in combination with clinical symptoms, we started therapy with balanced fluid intake and intravenous infusion of normotonic saline.
CONCLUSION
The development of SIADH as a rare adverse event with vinorelbine treatment has to be taken into consideration.
背景
抗利尿激素分泌不当综合征（SIADH）是化疗已知的一种罕见不良事件。我们报告了1例长春瑞滨治疗后发生SIADH的病例。
病例报告
一名79岁女性于2000年首次诊断出乳腺癌。首次诊断三年后，患者出现骨和肝转移。在接受第1疗程长春瑞滨姑息化疗7天后，患者出现意识减退、疲劳和身体虚弱。根据实验室检查结果结合临床症状诊断为SIADH后，我们开始采用平衡液体摄入量和静脉输注等渗盐水进行治疗。
结论
必须考虑到SIADH作为长春瑞滨治疗罕见不良事件的发生情况。
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