Acevedo Rocha C G, Alvarez E, Zafra de la Rosa G, Alvarez Navarro M, Gariglio P
Departamento de Genética y Biología Molecular, Centro de Investigación y Estudios Avanzados del IPN, CINVESTAV-IPN, DF México.
Ginecol Obstet Mex. 2007 Apr;75(4):205-13.
Microarray technology has remarkably accelerated the understanding of the molecular events of neoplasias. By means of gene expression profiles, a molecular subclassification of cancer patients and the identification of thousand of genes involved in this pathology have been achieved. Herein, the general use of DNA microarrays in cervical cancer tumorigenesis is reviewed. Finally, putative molecular tumour markers as useful factors in diagnosis, prognosis, and tailor-made therapy for this disease are proposed.
微阵列技术显著加速了对肿瘤形成分子事件的理解。通过基因表达谱，已实现对癌症患者的分子亚分类以及对数千个参与该病理过程的基因的识别。本文综述了DNA微阵列在宫颈癌发生中的普遍应用。最后，提出了潜在的分子肿瘤标志物作为该疾病诊断、预后和个性化治疗的有用因素。
