Baumgartner Christine, Bollerhey Melanie, Henke Julia, Wagner Silvia, Ungerer Martin, Erhardt Wolf
Working Group of Experimental Surgery, Institute for Experimental Oncology and Therapeutic Research, Technical University, Munich, Germany.
Vet Anaesth Analg. 2008 Mar;35(2):100-12. doi: 10.1111/j.1467-2995.2007.00360.x. Epub 2007 Sep 7.
To evaluate the cardiovascular effects of intravenous propofol in rabbits.
Randomized, prospective, experimental study.
Thirty-one female New Zealand White rabbits.
Rabbits were allocated to one of two groups [propofol (P) or conscious (C)]. In C (n = 16) vascular dimensions were measured using ultrasound of the left common carotid artery (ACC) and the abdominal aorta (AA). Group P (n = 15) received propofol 4.0-8.0 mg kg(-1) intravenously (IV). Anaesthesia was maintained with propofol at 1.2-1.3 mg kg(-1) minute(-1). Subsequently, three propofol injections (8 mg kg(-1)) were given. Before and for 10 minutes after each injection the following vascular and haemodynamic variables were recorded (a) at the ACC after the first injection; and (b) at the AA after the second injection: vessel diameter [D, (mm)], peak systolic, minimum diastolic, end-diastolic and average blood flow velocities [psBFV, mdBFV, edBFV, Vave (cm second(-1))], average volumetric flow [VFave (mL s(-1))], resistance index (RI) and pulsatility index (PI) mean arterial pressure (MAP), heart rate (HR), arterial oxygen saturation (SpO(2)) and end-tidal CO(2) (Pe'CO(2)). Echocardiography was performed after the third propofol bolus injection to investigate changes in cardiac parameters [fractional shortening, FS (%)].
Intravenous propofol injections caused a significant decrease in vessel diameter, volumetric flow and edBFV, and significant increases in psBFV, RI and PI. Baseline levels for vessel diameter and psBFV were restored 6-8 minutes after injection. Propofol injection decreased FS significantly by 7 minutes after injection while MAP and HR were significantly reduced for 4 minutes.
Injections of propofol (8 mg kg(-1)) produced an immediate, transient decrease in vascular diameters, a significant decrease in ventricular performance and an increase in peripheral vascular resistance (ACC and AA). Propofol should probably not be or only carefully used in rabbits with ventricular dysfunction.
评估静脉注射丙泊酚对家兔心血管系统的影响。
随机、前瞻性实验研究。
31只雌性新西兰白兔。
将家兔分为两组之一[丙泊酚组（P）或清醒组（C）]。在C组（n = 16）中，使用超声测量左颈总动脉（ACC）和腹主动脉（AA）的血管尺寸。P组（n = 15）静脉注射丙泊酚4.0 - 8.0 mg·kg⁻¹。用丙泊酚以1.2 - 1.3 mg·kg⁻¹·分钟⁻¹维持麻醉。随后，给予三次丙泊酚注射（8 mg·kg⁻¹）。在每次注射前及注射后10分钟记录以下血管和血流动力学变量：（a）第一次注射后在ACC处；（b）第二次注射后在AA处：血管直径[D，（mm）]、收缩期峰值、舒张期末最小值、舒张期末和平均血流速度[psBFV、mdBFV、edBFV、Vave（cm·秒⁻¹）]、平均容积流量[VFave（mL·秒⁻¹）]、阻力指数（RI）和搏动指数（PI）、平均动脉压（MAP）、心率（HR）、动脉血氧饱和度（SpO₂）和呼气末二氧化碳（Pe'CO₂）。在第三次丙泊酚推注后进行超声心动图检查，以研究心脏参数的变化[缩短分数，FS（%）]。
静脉注射丙泊酚导致血管直径、容积流量和edBFV显著降低，psBFV、RI和PI显著增加。注射后6 - 8分钟血管直径和psBFV的基线水平恢复。丙泊酚注射后7分钟FS显著降低，而MAP和HR在4分钟内显著降低。
注射丙泊酚（8 mg·kg⁻¹）可使血管直径立即出现短暂减小，心室功能显著降低，外周血管阻力（ACC和AA）增加。对于有心室功能障碍的家兔，可能不应使用丙泊酚或应谨慎使用。
