Pavone-Macaluso M, di Trapani D, Pavone C
Department of Urology, of Palermo, Italy.
Scand J Urol Nephrol Suppl. 1991;138:77-82.
The term 'chronic prostatitis syndrome' (C.P.S) encompasses chronic bacterial prostatitis, chlamydia or ureaplasma-associated disease, chronic 'abacterial' prostatitis, and patients with prostatosis or prostatosis or prostalgia. Interesting observations emerged from the evaluation of the clinical material indicating that the patients with abacterial prostatitis and those with prostatosis or prostaglia group have frequent sperm abnormalities and ultrasonographic changes suggesting a more complex pathogenesis than mere congestion and neurosis. Treatment in 144 evaluable patients treated with a long-acting sulphur-trimethoprim combination was almost uniformly well tolerated; Chlamydia was eradicated in all 10 treated patients and 77.4% of patients with bacterial C.P.S. were rendered free of bacteria. Sperm abnormalities were almost invariably resistant to the treatment. Only 44.4% of patients showed a partial improvement, limited to one or more parameters. Results did not differ significantly in the various subgroup. An overall evaluation of results showed that disappearance of every presenting symptom and sign was obtained in 24.3% and a significant improvement in another 25% of patients, including those in the prostatosis-prostalgia group. These results suggest that antibacterial treatment may be followed by favourable clinical results even in patients in whom no bacteria or other aetiological agents could be isolated.
“慢性前列腺炎综合征”（C.P.S）这一术语涵盖慢性细菌性前列腺炎、衣原体或脲原体相关疾病、慢性“无菌性”前列腺炎，以及前列腺痛或前列腺病患者。对临床资料的评估得出了一些有趣的观察结果，表明无菌性前列腺炎患者以及前列腺痛或前列腺病组患者经常出现精子异常和超声检查变化，这提示其发病机制比单纯的充血和神经官能症更为复杂。在144例接受长效磺胺甲恶唑联合治疗的可评估患者中，治疗耐受性几乎都很好；10例接受治疗的衣原体感染患者全部清除了衣原体，细菌性C.P.S患者中有77.4%的人细菌转阴。精子异常几乎始终对治疗有抗性。只有44.4%的患者有部分改善，仅限于一个或多个参数。各亚组结果差异不显著。结果的总体评估显示，24.3%的患者所有出现的症状和体征均消失，另有25%的患者，包括前列腺痛 - 前列腺病组患者，有显著改善。这些结果表明，即使在未分离出细菌或其他病原体的患者中，抗菌治疗也可能带来良好的临床效果。
