López José I
Department of Anatomic Pathology, Hospital de Basurto, Basque Country University (EHU/UPV), Bilbao, Spain.
BJU Int. 2007 Dec;100(6):1272-6. doi: 10.1111/j.1464-410X.2007.07122.x. Epub 2007 Sep 11.
To review specific histological variables in patients with prostate cancer who previously had diagnoses of high-grade prostatic intraepithelial neoplasia (HGPIN) and/or atypical small acinar proliferation (ASAP), compared with those who had no such diagnoses.
The histological characteristics of prostate cancers which were detected after a previous diagnosis of HGPIN and/or ASAP during 1998-2005 were investigated and correlated with the biopsies from patients with prostate cancer but with no such previous diagnoses.
HGPIN was followed by prostate cancer on repeat biopsy in 16.8% of patients, and ASAP in 26.7%. The mean age of patients with HGPIN or ASAP was higher than in those with no such diagnoses (P < 0.001). Similarly, patients with these previous diagnoses had a lower Gleason score (P = 0.017 and <0.001, respectively) and lower tumour volume variables (fewer tumour foci, P = 0.033 and 0.041, respectively) and shorter cancer (P = 0.048 and 0.030) in core biopsies than those without.
Patients with prostate cancer who had previous biopsies with HGPIN or ASAP were older and has lower grade- and volume-cancers than those who had not.
回顾既往诊断为高级别前列腺上皮内瘤变（HGPIN）和/或非典型小腺泡增生（ASAP）的前列腺癌患者的特定组织学变量，并与未进行此类诊断的患者进行比较。
对1998年至2005年间在先前诊断为HGPIN和/或ASAP后检测到的前列腺癌的组织学特征进行研究，并与前列腺癌但无此类先前诊断的患者的活检结果进行关联分析。
重复活检时，16.8%的HGPIN患者随后发生前列腺癌，26.7%的ASAP患者随后发生前列腺癌。有HGPIN或ASAP诊断的患者的平均年龄高于无此类诊断的患者（P<0.001）。同样，与无此类先前诊断的患者相比，这些有先前诊断的患者在穿刺活检中的Gleason评分较低（分别为P=0.017和<0.001）、肿瘤体积变量较低（肿瘤灶较少，分别为P=0.033和0.041）且癌灶较短（P=0.048和0.030）。
与未进行过此类活检的患者相比，先前活检诊断为HGPIN或ASAP的前列腺癌患者年龄更大，癌症分级和体积更低。
