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荷兰新生儿重症监护病房的个性化发育护理:短期临床结果

Individualized developmental care in a Dutch NICU: short-term clinical outcome.

作者信息

Wielenga J M, Smit B J, Merkus M P, Kok J H

机构信息

Department of Neonatology, Academic Medical Center/Emma Children's Hospital, Amsterdam, The Netherlands.

出版信息

Acta Paediatr. 2007 Oct;96(10):1409-15. doi: 10.1111/j.1651-2227.2007.00451.x. Epub 2007 Sep 10.

Abstract

AIM

To compare the short-term clinical outcomes of Newborn Individualized Developmental Care and Assessment Program (NIDCAP) and conventional care.

METHODS

A prospective phase-lag cohort study was performed in a Dutch tertiary level neonatal intensive care unit (NICU). Infants born before 30 weeks of gestational age (GA) were included, 26 in the conventional and 25 in the NIDCAP group. Outcomes were respiratory status, cerebral ultrasound findings, growth and length of NICU stay.

RESULTS

At study entry, NIDCAP infants had a lower birth weight (mean [SD]: 1043 [191] vs. 1154 [174] g, p = 0.044), were more often small for GA (8 vs. 2, p = 0.038), had smaller head circumferences (mean [SD]: 25.1 [1.3] vs. 26.1 [1.8] cm, p = 0.041) and were less often multiples (6 vs. 14, p = 0.029) than conventional care infants. During NICU stay, more infants in the NIDCAP group developed pneumonia (9 vs. 3, p = 0.040) due to nosocomial infections. After adjustment for these differences, a decreased risk for more severe cerebral damage in favour of NIDCAP was seen (Odds ratio: 0.12, 95% CI: 0.03-0.46, p = 0.002). No differences were observed for the other outcomes.

CONCLUSIONS

We conclude with precaution that in this phase-lag cohort study NIDCAP may have resulted in less severe cerebral damage, but was not associated with other clinical outcomes. In light of these findings, NIDCAP deserves further exploration.

摘要

目的

比较新生儿个体化发育照护与评估项目(NIDCAP)和传统护理的短期临床结局。

方法

在一家荷兰三级新生儿重症监护病房(NICU)进行了一项前瞻性阶段滞后队列研究。纳入孕周小于30周的婴儿,传统护理组26例,NIDCAP组25例。结局指标为呼吸状况、脑超声检查结果、生长情况及NICU住院时间。

结果

研究开始时,NIDCAP组婴儿出生体重较低(均值[标准差]:1043[191]g对1154[174]g,p = 0.044),小于胎龄儿比例更高(8例对2例,p = 0.038),头围更小(均值[标准差]:25.1[1.3]cm对26.1[1.8]cm,p = 0.041),多胞胎比例更低(6例对14例,p = 0.029)。在NICU住院期间,NIDCAP组更多婴儿因医院感染发生肺炎(9例对3例,p = 0.040)。在对这些差异进行调整后,发现NIDCAP组发生更严重脑损伤的风险降低(优势比:0.12,95%可信区间:0.03 - 0.46,p = 0.002)。其他结局指标未观察到差异。

结论

我们谨慎得出结论,在这项阶段滞后队列研究中,NIDCAP可能导致脑损伤较轻,但与其他临床结局无关。鉴于这些发现,NIDCAP值得进一步探索。

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