Hulse Gary K, Low Vincent H S, Stalenberg Virginia, Morris Noella, Thompson Richard I, Tait Robert J, Phan Cam T, Ngo Hanh T T, Arnold-Reed Diane E
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia.
Addict Biol. 2008 Sep;13(3-4):364-72. doi: 10.1111/j.1369-1600.2007.00081.x. Epub 2007 Sep 11.
Ultrasound was used to assess the in vivo biodegradability of a sustained release poly(DL)lactide naltrexone implant in 71 persons previously treated for heroin dependence. We assessed 139 implant sites ranging from 2 to 1808 days post implant. Ultrasound assessment showed that implant tablets were initially well demarcated from each other and from the surrounding tissues. Biodegradation resulted in less demarcated tablets followed by clumping into a single mass-like structure. This mass subsequently dispersed by approximately 1201 days post implant with no implant material visualized by ultrasound. The biodegradation was also assessed by visual clinical examination and palpation of the implant site as well as patient self-report. These measures were generally well correlated with ultrasound results. Clinical assessment of the biodegradation process concluded that the implant changed from 'firm' to 'less firm' and from 'initial square edge' to 'rounded edge' tablets. Collectively, these data provide direct evidence of the in vivo absorption of the Go Medical implant over time, and its biodegradability in humans.
超声被用于评估一种用于治疗海洛因依赖的缓释聚（DL）丙交酯纳曲酮植入物在71名曾接受过治疗的人体内的生物降解性。我们评估了植入后2至1808天的139个植入部位。超声评估显示，植入片剂最初彼此之间以及与周围组织界限分明。生物降解导致片剂界限不那么明显，随后聚集成单个块状结构。该块状物随后在植入后约1201天散开，超声未显示有植入材料。还通过对植入部位进行视觉临床检查、触诊以及患者自我报告来评估生物降解情况。这些措施通常与超声结果高度相关。对生物降解过程的临床评估得出结论，植入物从“坚硬”变为“较软”，片剂从“初始方形边缘”变为“圆形边缘”。总体而言，这些数据提供了Go Medical植入物在体内随时间吸收及其在人体内生物降解性的直接证据。
