Hu Dong, Zhang Rong-bo, Wu Jing
School of Medicine, Anhui University of Science and Technology, Huainan 232001, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2007 Apr;28(4):354-7.
To explore the effect of endotoxin concentration in dwellings on the prevalence of atopic asthma in children.
Standardized questionnaires of asthma were distributed to the parents of 2986 school children aged between 8 and 12 years and endotoxin content in children's mattress was measured by a kinetic limulus assay. A radioallergosorbent technique--fluorescence enzyme immunoassay (RAST-FEIA) was used to measure the level of specific IgE in serum.
Complete data was available for 904 children with males more than females. There were both negative associations seen between endotoxin levels and both atopic asthma (OR = 0.48, 95% CI: 0.32-0.72, P < 0.05) and atopic sensitization (OR = 0.65, 95% CI: 0.49-0.94, P < 0.05) but not with non-atopic asthma and wheeze. Comparing with normal people, patients with atopic sensitization, atopic wheeze and atopic asthma had a higher levels of endotoxin (M-W U: 15 138.0, P < 0.01, M-W U: 4858.0, P < 0.01, M-W U: 4041.0, P < 0.01).
Exposure to endotoxin in early lives of children might have a protective effect on atopic asthma and sensitization.
探讨住宅内内毒素浓度对儿童特应性哮喘患病率的影响。
向2986名8至12岁学童的家长发放标准化哮喘问卷，并采用动态鲎试剂法测定儿童床垫中的内毒素含量。采用放射变应原吸附技术-荧光酶免疫测定法（RAST-FEIA）测定血清中特异性IgE水平。
904名儿童有完整数据，男性多于女性。内毒素水平与特应性哮喘（OR = 0.48，95%CI：0.32-0.72，P < 0.05）和特应性致敏（OR = 0.65，95%CI：0.49-0.94，P < 0.05）均呈负相关，但与非特应性哮喘和喘息无关。与正常人相比，特应性致敏、特应性喘息和特应性哮喘患者的内毒素水平更高（M-W U：15138.0，P < 0.01，M-W U：4858.0，P < 0.01，M-W U：4041.0，P < 0.01）。
儿童早期接触内毒素可能对特应性哮喘和致敏有保护作用。
