Magro Gaetano, Gurrera Alessandra, Gangemi Piero, Saita Alberto, Greco Paolo
Dipartimento G.F. Ingrassia, Anatomia Patologica, Università di Catania, Via S. Sofia 87, 95123 Catania, Italy.
Pathol Res Pract. 2007;203(10):759-62. doi: 10.1016/j.prp.2007.05.011. Epub 2007 Sep 11.
The group of incompletely differentiated (unclassified) sex cord/gonadal stromal tumors includes rare cases with predominant spindle cell morphology. We report a rare case of a "pure" spindle cell tumor of the testis with morphological and immunohistochemical features consistent with the diagnosis of "incompletely differentiated sex cord/gonadal stromal tumor". Given the spindle cell morphology, the differential diagnosis with other benign and malignant spindle cell lesions is discussed. The concurrent presence of some morphological and immunohistochemical features of both Leydig and granulosa cell lines in the tumor suggests its origin from a stromal stem cell, possibly capable of dual differentiation, but with an arrest of maturation at an early phase of differentiation.
不完全分化（未分类）性索/性腺间质肿瘤组包括少数以梭形细胞形态为主的病例。我们报告一例罕见的睾丸“纯”梭形细胞瘤，其形态学和免疫组化特征符合“不完全分化性索/性腺间质肿瘤”的诊断。鉴于其梭形细胞形态，讨论了与其他良性和恶性梭形细胞病变的鉴别诊断。肿瘤中同时存在Leydig细胞系和颗粒细胞系的一些形态学和免疫组化特征，提示其起源于间质干细胞，可能具有双向分化能力，但在分化早期成熟受阻。
