基质金属蛋白酶-2启动子多态性与墨西哥人群中的乳腺癌相关。
Matrix metalloproteinase-2 promoter polymorphism is associated with breast cancer in a Mexican population.
作者信息
Delgado-Enciso Iván, Cepeda-Lopez Friedman R, Monrroy-Guizar Elisa A, Bautista-Lam Jose R, Andrade-Soto Maricela, Jonguitud-Olguin Gregorio, Rodriguez-Hernandez Alejandrina, Anaya-Ventura Aristoteles, Baltazar-Rodriguez Luz M, Orozco-Ruiz Martha, Soriano-Hernandez Alejandro D, Rodriguez-Sanchez Iram P, Lugo-Trampe Angel, Espinoza-Gomez Francisco, Michel-Peregrina Martha L
机构信息
School of Medicine, Universidad de Colima, Colima, Col., Mexico.
出版信息
Gynecol Obstet Invest. 2008;65(1):68-72. doi: 10.1159/000108282. Epub 2007 Sep 13.
BACKGROUND
Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity on matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism C>T transition at -1306 displayed a strong association with several cancers. Our study investigated whether or not the MMP-2 -1306C>T polymorphism contributed to the development of breast cancer (BC) in a Mexican population.
METHODS
90 patients with BC and 96 control subjects were analyzed to detect MMP-2 -1306C>T polymorphism.
RESULTS
The frequency of MMP-2 CC genotype was significantly higher in BC patients when compared with the control group (OR 2.15; 95% CI 1.1-4.1). MMP-2 CC genotype frequency was more pronounced in younger subjects (< or =50 years) at diagnosis (OR 2.66; 95% CI 1.04-6.96).
CONCLUSION
The data suggest that MMP-2 -1306C>T polymorphism strongly contributes to the development of BC in the population studied, especially among women 50 years old and younger.
背景
基质金属蛋白酶-2（MMP-2）是一种对基质蛋白尤其是基底膜成分具有蛋白水解活性的酶。-1306位点的单核苷酸多态性C>T转换与多种癌症密切相关。我们的研究调查了MMP-2 -1306C>T多态性是否与墨西哥人群乳腺癌（BC）的发生有关。
方法
对90例乳腺癌患者和96例对照者进行分析，以检测MMP-2 -1306C>T多态性。
结果
与对照组相比，乳腺癌患者中MMP-2 CC基因型的频率显著更高（比值比2.15；95%置信区间1.1 - 4.1）。在诊断时年龄较小（≤50岁）的受试者中，MMP-2 CC基因型频率更为明显（比值比2.66；95%置信区间1.04 - 6.96）。
结论
数据表明，MMP-2 -1306C>T多态性在所研究人群中对乳腺癌的发生有很大影响，尤其是在50岁及以下的女性中。
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