Białkowska Katarzyna, Marciniak Wojciech, Muszyńska Magdalena, Baszuk Piotr, Gupta Satish, Jaworska-Bieniek Katarzyna, Sukiennicki Grzegorz, Durda Katarzyna, Gromowski Tomasz, Lener Marcin, Prajzendanc Karolina, Łukomska Alicja, Cybulski Cezary, Huzarski Tomasz, Gronwald Jacek, Dębniak Tadeusz, Lubiński Jan, Jakubowska Anna
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Read-Gene S.A., Grzepnica, Poland.
Hered Cancer Clin Pract. 2020 Jul 31;18:16. doi: 10.1186/s13053-020-00147-w. eCollection 2020.
Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon.
The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon cancer) and 648 unaffected individuals. Five SNPs, rs1799750 in rs243865 in rs11568818 in rs2252070 in and rs28366003 in were genotyped and serum zinc (Zn) level was measured. The cancer risk was calculated using multivariable logistic regression with respect to Zn.
None of the 5 tested polymorphisms showed a correlation with cancer risk in studied groups, although for , and non-significant differences in genotypes frequencies among cases and controls were observed.
Analyses of polymorphisms, rs1799750 in , rs243865 in , rs11568818 in , rs2252070 in and rs28366003 in in relation to serum Zn level did not show significant association with breast, lung and colon cancer risk among polish patients. Further studies are needed to verify this observation.
基质金属蛋白酶（MMPs）和金属硫蛋白（MTs）是与锌相关的蛋白质，它们参与了诸如血管生成、增殖和凋亡等对癌症发生至关重要的过程。MMPs和MTs中一些影响基因表达的单核苷酸多态性（SNPs）已与癌症风险相关，包括乳腺癌、肺癌和结肠癌。
研究组由648例未经选择的患者（299例乳腺癌患者、199例肺癌患者、150例结肠癌患者）和648例未受影响的个体组成。对5个单核苷酸多态性位点，即位于[具体基因1]的rs1799750、位于[具体基因2]的rs243865、位于[具体基因3]的rs11568818、位于[具体基因4]的rs2252070以及位于[具体基因5]的rs28366003进行基因分型，并测量血清锌（Zn）水平。使用多变量逻辑回归分析计算锌相关的癌症风险。
在所研究的组中，5个检测的多态性位点均未显示与癌症风险相关，尽管对于[某些具体位点]，在病例组和对照组之间观察到基因型频率存在非显著性差异。
对位于[具体基因1]的rs1799750、位于[具体基因2]的rs243865、位于[具体基因3]的rs11568818、位于[具体基因4]的rs2252070以及位于[具体基因5]的rs28366003与血清锌水平关系的分析表明，在波兰患者中，这些多态性与乳腺癌、肺癌和结肠癌风险之间未显示出显著关联。需要进一步研究来验证这一观察结果。
