卡马西平可减轻大鼠水杨酸盐治疗后耳鸣的行为表现。
Carbamazepine reduces the behavioural manifestations of tinnitus following salicylate treatment in rats.
作者信息
Zheng Yiwen, Hooton Katie, Smith Paul F, Darlington Cynthia L
机构信息
Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New Zealand.
出版信息
Acta Otolaryngol. 2008 Jan;128(1):48-52. doi: 10.1080/00016480701361939.
CONCLUSION
The results are consistent with the hypothesis that carbarmazepine (CBZ) has efficacy against tinnitus in humans.
OBJECTIVE
CBZ is an anti-epileptic drug that is widely used for the treatment of tinnitus. Despite this, there are relatively few clinical trials or preclinical studies supporting its efficacy. In an effort to increase the amount of information available on CBZ, the aim of this study was to investigate the efficacy of CBZ in salicylate-induced tinnitus in rats
MATERIALS AND METHODS
We investigated the effects of CBZ in an animal model of tinnitus induced by the injection of salicylate using a conditioned lick suppression paradigm.
RESULTS
We found that CBZ, at a dose of 15 mg/kg i.p., but not at 5 mg/kg or 30 mg/ kg, significantly suppressed the behavioural manifestations of tinnitus.
结论
结果与卡马西平（CBZ）对人类耳鸣具有疗效这一假设相符。
目的
CBZ是一种抗癫痫药物，广泛用于治疗耳鸣。尽管如此，支持其疗效的临床试验或临床前研究相对较少。为了增加有关CBZ的可用信息量，本研究的目的是调查CBZ对大鼠水杨酸盐诱导耳鸣的疗效。
材料与方法
我们使用条件性舔舐抑制范式，研究了CBZ对注射水杨酸盐诱导的耳鸣动物模型的影响。
结果
我们发现，腹腔注射剂量为15mg/kg的CBZ可显著抑制耳鸣的行为表现，而5mg/kg或30mg/kg剂量则无此效果。
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