Rentzos Michael, Nikolaou Chryssoula, Rombos Antonis, Boufidou Fotini, Zoga Margarita, Dimitrakopoulos Antonis, Tsoutsou Anthousa, Vassilopoulos Demetrios
Neurology, Aeginition Hospital, Athens National University, School of Medicine, Athens, Greece.
Amyotroph Lateral Scler. 2007 Oct;8(5):283-7. doi: 10.1080/17482960701419232.
Immunological disturbances have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Chemokines are involved in the recruitment of immune cells. Regulated upon activation, normal T-cell expressed and secreted (RANTES) is a C-C beta-chemokine with strong chemo-attractant activity for T-lymphocytes and monocytes. We examined serum levels of RANTES in 20 patients with amyotrophic lateral sclerosis (ALS), 14 patients with non-inflammatory neurological disorders (NIND) and 13 control subjects (CTRL) and cerebrospinal fluid (CSF) levels of RANTES in ALS and NIND group patients in order to investigate whether RANTES as index of immune activation is present in ALS patients. Patients with ALS had higher RANTES levels compared with the NIND patients and CTRL subjects (p = 0.005 and p = 0.02, respectively). CSF RANTES levels were also higher compared with the NIND patients (p = 0.007). No correlation of serum and CSF RANTES levels with disease duration was found. These results may suggest an activated microglia induced recruitment of peripheral inflammatory cells to sites of inflammation in ALS patients.
免疫紊乱被认为与肌萎缩侧索硬化症（ALS）的发病机制有关。趋化因子参与免疫细胞的募集。活化调节正常T细胞表达和分泌因子（RANTES）是一种C-Cβ趋化因子，对T淋巴细胞和单核细胞具有很强的化学吸引活性。我们检测了20例肌萎缩侧索硬化症（ALS）患者、14例非炎性神经系统疾病（NIND）患者和13例对照者（CTRL）的血清RANTES水平，以及ALS组和NIND组患者的脑脊液（CSF）RANTES水平，以研究RANTES作为免疫激活指标在ALS患者中是否存在。与NIND患者和对照者相比，ALS患者的RANTES水平更高（分别为p = 0.005和p = 0.02）。与NIND患者相比，脑脊液RANTES水平也更高（p = 0.007）。未发现血清和脑脊液RANTES水平与病程之间存在相关性。这些结果可能提示活化的小胶质细胞诱导外周炎性细胞募集至ALS患者的炎症部位。
