Iłzecka J
Department of Neurology, Medical University, Lublin, Poland.
Acta Neurol Scand. 2008 May;117(5):343-6. doi: 10.1111/j.1600-0404.2007.00947.x. Epub 2007 Nov 8.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. Previously, it was showed that apoptosis may play a role in the pathomechanisms of this disease. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine with proapoptotic activity in the central nervous system. The aim of the study was to measure serum TRAIL levels in patients with ALS.
The study involved 25 patients with ALS and 20 controls. Serum TRAIL levels were performed by the enzyme-linked immunosorbent method.
Study showed that TRAIL levels were significantly decreased in the serum of patients with ALS compared with controls (P < 0.05). There was no significant correlation between serum TRAIL levels and clinical parameters of ALS (P > 0.05).
A decrease in serum TRAIL levels in patients with ALS suggests that this cytokine may be implicated in the pathomechanisms of this disease.
肌萎缩侧索硬化症（ALS）是一种神经退行性疾病。此前研究表明，细胞凋亡可能在该疾病的发病机制中起作用。肿瘤坏死因子相关凋亡诱导配体（TRAIL）是一种在中枢神经系统中具有促凋亡活性的细胞因子。本研究旨在测定ALS患者血清中TRAIL的水平。
该研究纳入了25例ALS患者和20例对照。采用酶联免疫吸附法检测血清TRAIL水平。
研究显示，与对照组相比，ALS患者血清中TRAIL水平显著降低（P < 0.05）。血清TRAIL水平与ALS临床参数之间无显著相关性（P > 0.05）。
ALS患者血清TRAIL水平降低表明，这种细胞因子可能参与了该疾病的发病机制。
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