Chung Christina K, Linsenmeier Robert A
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208-3107, USA.
Curr Eye Res. 2007 Jul-Aug;32(7-8):699-707. doi: 10.1080/02713680701459250.
This work assessed the relative effects of inspiring carbogen (95% O(2)/5% CO2) and 100% O2 on intraretinal PO2 and oxygen consumption in the cat retina. Oxygen microelectrodes were used to measure the distribution of oxygen in the central retina of dark-adapted anesthetized cats during normoxia, 100% O2 breathing, and carbogen breathing. Profiles of oxygen tension (PO2) as a function of retinal depth were recorded. Changes in PO2 caused by the transient administration of carbogen and 100% oxygen were also measured at selected retinal depths. Average PO2 values at the choroid, at the boundary between the inner and outer retina, and across the inner retina were significantly higher during inspiration of carbogen than 100% O2. There were no significant differences among conditions in outer retinal oxygen consumption. During the transient gas administration, average changes in PO2 generally increased with depth. At the end of gas administration, the decay of PO2 within the retina occurred quickly, meaning that short-term gas administration may have little therapeutic value.
这项研究评估了吸入卡波金（95% O₂/5% CO₂）和100% O₂对猫视网膜内PO₂及氧消耗的相对影响。使用氧微电极测量了在常氧、100% O₂呼吸和卡波金呼吸期间，暗适应麻醉猫中央视网膜内的氧分布情况。记录了氧张力（PO₂）随视网膜深度变化的曲线。还在选定的视网膜深度测量了卡波金和100%氧气短暂给药引起的PO₂变化。吸入卡波金时，脉络膜、视网膜内外边界以及整个视网膜内层的平均PO₂值显著高于吸入100% O₂时。视网膜外层的氧消耗在不同条件下无显著差异。在短暂气体给药期间，PO₂的平均变化通常随深度增加。在气体给药结束时，视网膜内PO₂迅速下降，这意味着短期气体给药可能几乎没有治疗价值。
