Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Gynecol Endocrinol. 2007;23(8):468-73. doi: 10.1080/09513590701507817.
Secretion of growth hormone (GH) is known to be suppressed in women with polycystic ovary syndrome (PCOS). The suppression may be implicated in the pathogenesis of PCOS.
To investigate the cause of suppressive GH secretion in PCOS.
In order to eliminate the influence of obesity on the variables, all subjects were non-obese. Standard oral glucose tolerance tests (OGTT) were performed in 13 normal women and 15 patients with PCOS.
The serum GH level decreased progressively during the OGTT, and the mean area under the curve (AUC) for the GH response was significantly smaller in the PCOS group than in the normal group. A reduction in the level of serum free fatty acids (FFAs) was observed during OGTT, but only the fasting level of FFAs was significantly higher in the PCOS group than in the normal group. The mean AUCs for glucose, insulin and FFA responses in the PCOS group were significantly greater than those in the normal group. There was a significant negative correlation only between AUC(GH) and testosterone (r = -0.4557, p = 0.012).
Our findings suggest that the cause of susceptibility for GH secretion to be suppressed after glucose loading in non-obese PCOS patients may be hyperandrogenemia.
已知多囊卵巢综合征（PCOS）患者的生长激素（GH）分泌受到抑制。这种抑制可能与 PCOS 的发病机制有关。
探讨 PCOS 中 GH 分泌受抑制的原因。
为了消除肥胖对变量的影响，所有受试者均非肥胖。对 13 名正常女性和 15 名 PCOS 患者进行了标准口服葡萄糖耐量试验（OGTT）。
OGTT 期间血清 GH 水平逐渐下降，PCOS 组的 GH 反应曲线下面积（AUC）明显小于正常组。OGTT 期间观察到血清游离脂肪酸（FFA）水平降低，但仅 PCOS 组的空腹 FFA 水平明显高于正常组。PCOS 组的血糖、胰岛素和 FFA 反应 AUC 均明显大于正常组。仅 GH 与睾酮之间存在显著负相关（r = -0.4557，p = 0.012）。
我们的研究结果表明，非肥胖 PCOS 患者葡萄糖负荷后 GH 分泌易受抑制的原因可能是高雄激素血症。
