甲氨蝶呤-倍他米松每周口服脉冲疗法治疗银屑病

Methotrexate-betamethasone weekly oral pulse in psoriasis.

作者信息

Gupta Ramji, Gupta Sarthak

机构信息

Department of Dermatology, Vidyasagar Institute of Mental Health and Neurosciences, New Delhi, India.

出版信息

J Dermatolog Treat. 2007;18(5):291-4. doi: 10.1080/09546630701487643.

DOI:10.1080/09546630701487643

PMID:17852636

Abstract

OBJECTIVES

Methotrexate in psoriasis helps to clear the lesions fast but remission is short. To produce long-term remission, methotrexate has been combined with betamethasone.

METHODS

A total of 40 patients with psoriasis (plaque type: 36, erythrodermic: four) were included in an open randomized study. Twenty-eight patients received weekly 15 mg methotrexate and 3 mg betamethasone orally and 12 patients received weekly 15 mg methotrexate orally alone until the Psoriasis Area Severity Index (PASI) scores were reduced to 95-100% of the baseline scores. Follow-up was carried out until relapse of the lesions.

RESULTS

Methotrexate combined with betamethasone orally weekly cleared the lesions in 27.13+/-2.39 (24.74-29.52) days with a remission period of 91.78+/-14.19 (77.59-105.97) days, whereas methotrexate alone took 33.09+/-5.61 (27.48-38.70) days to clear the lesions with a remission period of 20.30+/-2.50 (17.80-22.80) days.

CONCLUSIONS

Methotrexate combined with betamethasone cleared the lesions faster and with a longer remission period compared with methotrexate alone.

摘要

目的

甲氨蝶呤用于治疗银屑病可快速清除皮损，但缓解期较短。为实现长期缓解，甲氨蝶呤已与倍他米松联合使用。

方法

40例银屑病患者（斑块型36例，红皮病型4例）纳入一项开放性随机研究。28例患者每周口服15毫克甲氨蝶呤和3毫克倍他米松，12例患者仅每周口服15毫克甲氨蝶呤，直至银屑病面积和严重程度指数（PASI）评分降至基线评分的95 - 100%。随访至皮损复发。

结果

甲氨蝶呤联合倍他米松每周口服，皮损在27.13±2.39（24.74 - 29.52）天内清除，缓解期为91.78±14.19（77.59 - 105.97）天；而单用甲氨蝶呤清除皮损需时33.09±5.61（27.48 - 38.70）天，缓解期为20.30±2.50（17.80 - 22.80）天。