Castro Jose G, Manzi Gabriel, Espinoza Luis, Campos Michael, Boulanger Catherine
Division of Infectious Diseases, University of Miami Miller School of Medicine, Florida, USA.
Scand J Infect Dis. 2007;39(11-12):1054-8. doi: 10.1080/00365540701472056. Epub 2007 Jun 21.
We aimed to assess the incidence and clinical characteristics of patients with HIV infection with concurrent Pneumocystis pneumonia (PCP) and tuberculosis (TB). We carried out a retrospective record review of HIV infected patients admitted with pulmonary TB and PCP during the same hospital admission at a large county hospital in Miami, from 1995 to 2004. 2651 patients with HIV infection and possible TB or PCP were identified. There were 99 cases of PCP (81 presumptive and 18 confirmed) and 35 were new cases of TB. There were 17 patients who had a new, concurrent diagnosis of pulmonary TB and PCP. Approximately half of these patients were unaware of their HIV infections and half of them had a negative AFB in sputum. Most were men and had a CD4 count less than 100 cells/mm(3). Chest X-ray disclosed bilateral infiltrates in most of the cases. All but 2 survived the hospital admission. Thus, concurrent TB and PCP in HIV infected patients were not uncommon in this large county hospital in Miami, Florida in the studied period, but its diagnosis was challenging.
我们旨在评估合并肺孢子菌肺炎（PCP）和结核病（TB）的HIV感染患者的发病率及临床特征。我们对1995年至2004年期间在迈阿密一家大型县医院同一住院期间因肺结核和PCP入院的HIV感染患者进行了回顾性病历审查。共识别出2651例HIV感染且可能患有TB或PCP的患者。其中有99例PCP（81例疑似和18例确诊），35例为TB新发病例。有17例患者同时新诊断出肺结核和PCP。这些患者中约一半不知道自己感染了HIV，且一半患者痰涂片抗酸杆菌阴性。大多数为男性，CD4细胞计数低于100个/mm³。大多数病例胸部X线显示双侧浸润影。除2例患者外，其余均存活至出院。因此，在研究期间，在佛罗里达州迈阿密的这家大型县医院中，HIV感染患者合并TB和PCP并不少见，但其诊断具有挑战性。
