Brucker C, Karck U, Merkle E
Department of Obstetrics and Gynaecology, Nuernberg Hospital, Nuernberg, Germany.
Eur J Contracept Reprod Health Care. 2008 Mar;13(1):31-8. doi: 10.1080/13625180701577122.
To investigate the real-life clinical experience of NuvaRing users in Germany.
An open-label, prospective, uncontrolled, non-randomized, multicentre postmarketing surveillance study was conducted by 1204 gynaecologists amongst 5823 women requesting contraception. The women underwent routine examinations and contraceptive counselling, and were assessed after three and six cycles of NuvaRing use.
Good cycle control was observed and there was a reduction in cycle irregularity and inter-menstrual bleeding, bleeding duration and intensity, and dysmenorrhoea. NuvaRing was well tolerated, and had no significant effect on body weight or blood pressure. Nine women became pregnant unintentionally (two had conceived before they started to use NuvaRing, three due to non-compliance, one because of repeated ring expulsion/loss and three during treatment in spite of having applied this latter as instructed). Most women expressed their satisfaction with NuvaRing; 82% were 'very satisfied/ satisfied', 72% planned to continue using it and 82% would recommend it to others. More than 90% of women found NuvaRing 'without problems/easy' to insert and to remove, and more than 80% of the women and their partners were not disturbed by its presence during intercourse.
NuvaRing is a highly effective and acceptable method of once-monthly contraception that is safe and well tolerated.
调查德国优思明使用者的实际临床经验。
1204名妇科医生对5823名要求避孕的女性进行了一项开放标签、前瞻性、非对照、非随机、多中心的上市后监测研究。这些女性接受了常规检查和避孕咨询，并在使用优思明三个周期和六个周期后进行了评估。
观察到周期控制良好，周期不规则、经间期出血、出血持续时间和强度以及痛经均有所减少。优思明耐受性良好，对体重或血压无显著影响。9名女性意外怀孕（2名在开始使用优思明之前怀孕，3名由于未遵医嘱，1名因反复出现环脱落/丢失，3名在尽管按指示使用该药的情况下仍在治疗期间怀孕）。大多数女性对优思明表示满意；82%“非常满意/满意”，72%计划继续使用，82%会向他人推荐。超过90%的女性认为优思明插入和取出“没有问题/容易”，超过80%的女性及其伴侣在性交期间不会因它的存在而感到困扰。
优思明是一种高效且可接受的每月一次避孕方法，安全且耐受性良好。
