Dirikx Trinette, Beckers Tom, Muyls Clara, Eelen Paul, Vansteenwegen Debora, Hermans Dirk, D'Hooge Rudi
Department of Psychology, University of Leuven, Leuven, Belgium.
Q J Exp Psychol (Hove). 2007 Oct;60(10):1313-20. doi: 10.1080/17470210701515785.
In animals, the reappearance of conditioned fear responses after extinction has been primarily investigated using single-cue conditioning paradigms. However, a differential paradigm can overcome several of the disadvantages associated with a single-cue procedure. In the present study, the reinstatement phenomenon was assessed in mice using a differential conditioned suppression paradigm. In a first phase, one conditioned stimulus (CS + ) was consistently paired with an unconditioned stimulus (US; footshock) while another CS (CS-) was not, resulting in selective suppression of previously trained instrumental behaviour during the CS + . After the extinction phase, half of the animals (reinstatement group) were presented with unsignalled USs, while the other half were not (control group). A differential return of conditioned responding was observed in the reinstatement group, but not in the control group. The implications of these findings for future conditioning research are discussed.
在动物中，消退后条件性恐惧反应的重现主要是通过单线索条件作用范式进行研究的。然而，差异范式可以克服与单线索程序相关的几个缺点。在本研究中，使用差异条件性抑制范式在小鼠中评估了恢复现象。在第一阶段，一个条件刺激（CS +）始终与一个非条件刺激（US；足部电击）配对，而另一个CS（CS-）则不配对，导致在CS +期间对先前训练的工具性行为进行选择性抑制。在消退阶段之后，一半的动物（恢复组）接受无信号的USs，而另一半则不接受（对照组）。在恢复组中观察到了条件反应的差异恢复，但在对照组中没有。讨论了这些发现对未来条件作用研究的意义。
