Michielsen P J S, Thunnissen M M, Van Den Bossche B
GGZ Westelijk Noord Brabant, Postbus 371,4600 AJ Bergen op Zoom.
Tijdschr Psychiatr. 2007;49(9):655-9.
A 25-year-old woman, known to have schizoaffective disorder, presented with symptoms that had arisen a few weeks earlier. The symptoms indicated that she had a toxic clozapine blood level. The probable cause of the toxicity was a pharmacokinetic interaction between citalopram and clozapine at the level of the cytochrome P450 system. A literature search reveals the importance of monitoring the interactions between selective serotonin reuptake inhibitors and clozapine, a procedure which should, if possible, be accompanied by blood level measurements. Caution is called for, particularly when non-smokers are involved.
一名25岁的女性，已知患有分裂情感性障碍，出现了几周前开始的症状。这些症状表明她的氯氮平血药浓度达到了中毒水平。中毒的可能原因是西酞普兰和氯氮平在细胞色素P450系统水平上发生了药代动力学相互作用。文献检索揭示了监测选择性5-羟色胺再摄取抑制剂与氯氮平之间相互作用的重要性，如有可能，这一过程应伴有血药浓度测量。尤其在涉及非吸烟者时需要谨慎。
