10,11-二脱氢金鸡纳生物碱的改进合成方法。
An improved synthesis of 10,11-didehydro Cinchona alkaloids.
作者信息
Kacprzak Karol M, Lindner Wolfgang, Maier Norbert M
机构信息
Department of Analytical Chemistry and Food Chemistry, University of Vienna, Vienna, Austria.
出版信息
Chirality. 2008 Mar;20(3-4):441-5. doi: 10.1002/chir.20461.
A revised procedure for the conversion of the four major Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) into their respective 10,11-didehydro derivatives is described. The reported protocol offers several advantages over a recently published synthetic route. These include (i) enhanced robustness (ii) ready scalability (iii) reduced operational complexity and number of steps (iv) chromatography-free work-up. In addition, toxic solvents were replaced by environmentally less problematic alternatives.
描述了一种将四种主要金鸡纳生物碱（奎宁、奎尼丁、辛可尼定和辛可宁）转化为各自的10,11-二脱氢衍生物的改进方法。与最近发表的合成路线相比，所报道的方案具有几个优点。这些优点包括：（i）增强的稳健性；（ii）易于扩大规模；（iii）降低操作复杂性和步骤数量；（iv）无需色谱法后处理。此外，有毒溶剂被环境问题较少的替代品所取代。
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