Sakurai I
Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.
Acta Pathol Jpn. 1991 Dec;41(12):865-73. doi: 10.1111/j.1440-1827.1991.tb01631.x.
Coronary artery spasm is undoubtedly one of the causative factors of ischemic heart disease, particularly variant-type angina pectoris and myocardial infarction, but the disease mechanisms involved are still unclear. The present review describes the clinical background of coronary artery spasm in relation to ischemic heart disease, including a brief history of studies in this field, and also suggests future guidelines for experimental investigations based on the characteristics of coronary artery spasm, focusing particularly on data we have obtained in our laboratory from studies of cholinergic constriction. The pig may be a suitable animal in which coronary artery spasm could be provoked with cholinergic agents following endothelial denudation. The use of such large animals would allow the study of spastic arterial segments by various methods with angiographic confirmation. After endothelial denudation it is possible that phenotypic changes in cholinergic receptors might occur in smooth muscle cells, and that such changes might remain even after endothelial repair.
冠状动脉痉挛无疑是缺血性心脏病的致病因素之一，尤其是变异型心绞痛和心肌梗死，但其中涉及的发病机制仍不清楚。本综述描述了与缺血性心脏病相关的冠状动脉痉挛的临床背景，包括该领域的研究简史，并根据冠状动脉痉挛的特征提出了未来实验研究的指导方针，特别关注我们实验室从胆碱能收缩研究中获得的数据。猪可能是一种合适的动物，在内皮剥脱后可用胆碱能药物诱发冠状动脉痉挛。使用这样的大型动物将允许通过各种方法研究痉挛性动脉节段并进行血管造影确认。内皮剥脱后，平滑肌细胞中的胆碱能受体可能会发生表型变化，并且即使在内皮修复后这种变化可能仍然存在。
