Brandt-Christensen Mette, Kvist Kajsa, Nilsson Flemming Mørkeberg, Andersen Per Kragh, Kessing Lars Vedel
Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Denmark.
Mov Disord. 2007 Oct 31;22(14):2037-42. doi: 10.1002/mds.21472.
Depressive symptoms and major depression are frequent in patients with Parkinson's disease (PD). However, a systematic knowledge about the treatment with antidepressant drugs among PD patients is missing. We estimated the frequency of antidepressant drug treatment in a national sample of persons treated with antiparkinson drugs (APDs). All persons treated with APDs were identified in the national Danish Prescription database. The subsequent risk of treatment with antidepressants was estimated and compared with the risks for two large control groups. The study period was 5 years. In total, 1,029,737 persons were included. Persons who got APDs had significantly increased rate ratios (RR) of subsequent antidepressant drug treatment compared with an unexposed control group (RR: 2.10 (95% CI: 2.04-2.16)) and with persons who got anti-diabetic drugs [RR: 1.58 (95% CI: 1.51-1.65)]. Persons treated with APDs have higher frequency of antidepressant drug treatment than have controls. With the reservation that data on drug consumption cannot be directly transferred into conclusions about specific diseases, the present study supports results from other population-based studies of an association between PD and depression.
抑郁症状和重度抑郁症在帕金森病（PD）患者中很常见。然而，目前尚缺乏关于帕金森病患者使用抗抑郁药物治疗的系统性知识。我们在一个接受抗帕金森药物（APD）治疗的全国性样本中估计了抗抑郁药物治疗的频率。所有接受APD治疗的人都在丹麦国家处方数据库中被识别出来。随后估计了使用抗抑郁药物治疗的风险，并与两个大型对照组的风险进行了比较。研究期为5年。总共纳入了1,029,737人。与未暴露的对照组相比，接受APD治疗的人后续使用抗抑郁药物治疗的率比（RR）显著增加（RR：2.10（95%CI：2.04 - 2.16）），与接受抗糖尿病药物治疗的人相比也是如此[RR：1.58（95%CI：1.51 - 1.65）]。接受APD治疗的人使用抗抑郁药物治疗的频率高于对照组。尽管药物消费数据不能直接转化为关于特定疾病的结论，但本研究支持了其他基于人群的研究中关于帕金森病与抑郁症之间关联的结果。
