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From bed to bench: which attitude towards the laboratory liver tests should health care practitioners strike?从临床到实验室研究:医疗从业者对实验室肝脏检测应持何种态度?
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本文引用的文献

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Ultracentrifugation of serum samples allows detection of hepatitis C virus RNA in patients with occult hepatitis C.血清样本的超速离心法可检测出隐匿性丙型肝炎患者体内的丙型肝炎病毒RNA。
J Virol. 2007 Jul;81(14):7710-5. doi: 10.1128/JVI.02750-06. Epub 2007 May 2.
2
Biomarkers of liver fibrosis: clinical translation of molecular pathogenesis or based on liver-dependent malfunction tests.肝纤维化的生物标志物:分子发病机制的临床转化还是基于肝脏相关功能异常检测
Clin Chim Acta. 2007 Jun;381(2):107-13. doi: 10.1016/j.cca.2007.02.038. Epub 2007 Feb 27.
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Alcohol and hepatitis C mortality among males and females in the United States: a life table analysis.美国男性和女性中酒精与丙型肝炎死亡率:生命表分析
Alcohol Clin Exp Res. 2007 Feb;31(2):285-92. doi: 10.1111/j.1530-0277.2006.00304.x.
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Serum concentrations of the tissue polypeptide specific antigen in patients suffering from non-alcoholic steatohepatitis.非酒精性脂肪性肝炎患者血清组织多肽特异性抗原浓度
Eur J Clin Invest. 2007 Jan;37(1):48-53. doi: 10.1111/j.1365-2362.2007.01745.x.
5
Do we still need a liver biopsy? Are the serum fibrosis tests ready for prime time?我们仍然需要肝活检吗?血清纤维化检测准备好投入实际应用了吗?
Clin Liver Dis. 2006 Aug;10(3):513-34, viii. doi: 10.1016/j.cld.2006.08.009.
6
Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study.γ-谷氨酰转移酶与代谢综合征、心血管疾病及死亡风险:弗雷明汉心脏研究
Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):127-33. doi: 10.1161/01.ATV.0000251993.20372.40. Epub 2006 Nov 9.
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Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease.非酒精性脂肪性肝病中肝细胞内p53、Bax和Bcl-2蛋白的表达
World J Gastroenterol. 2006 Oct 14;12(38):6198-202. doi: 10.3748/wjg.v12.i38.6198.
8
Three-year increase of gamma-glutamyltransferase level and development of type 2 diabetes in middle-aged men and women: the D.E.S.I.R. cohort.中年男性和女性γ-谷氨酰转移酶水平的三年变化及2型糖尿病的发生:D.E.S.I.R.队列研究
Diabetologia. 2006 Nov;49(11):2599-603. doi: 10.1007/s00125-006-0418-x. Epub 2006 Sep 13.
9
gamma-Glutamyltransferase is a promising biomarker for cardiovascular risk.γ-谷氨酰转移酶是一种很有前景的心血管风险生物标志物。
Med Hypotheses. 2006;67(5):1060-4. doi: 10.1016/j.mehy.2006.04.010. Epub 2006 Aug 7.
10
Reliability of total overnight salivary caffeine assessment (TOSCA) for liver function evaluation in compensated cirrhotic patients.总夜间唾液咖啡因评估(TOSCA)在代偿期肝硬化患者肝功能评估中的可靠性。
Eur J Clin Pharmacol. 2006 Aug;62(8):605-12. doi: 10.1007/s00228-006-0146-7. Epub 2006 Jul 14.

从临床到实验室研究:医疗从业者对实验室肝脏检测应持何种态度?

From bed to bench: which attitude towards the laboratory liver tests should health care practitioners strike?

作者信息

Tarantino Giovanni

出版信息

World J Gastroenterol. 2007 Oct 7;13(37):4917-23. doi: 10.3748/wjg.v13.i37.4917.

DOI:10.3748/wjg.v13.i37.4917
PMID:17854131
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4434613/
Abstract

There is a general consensus in re-interpreting the so-called liver function tests in the light of novel discoveries. At the same time, recent evidence favours the use of different laboratory data to assess liver damage, fibrosis or regenerative process, but this point is not always shared. Actually, balancing the need for diagnosis, prognostic evaluation and therapy response of liver disease with a good cost/benefit ratio is very difficult. New tests are probably not needed but the aim should be for better utilization of existing tests to contain the increasing cost of health care.

摘要

根据新的发现重新解读所谓的肝功能测试已达成普遍共识。与此同时,近期证据支持使用不同的实验室数据来评估肝损伤、纤维化或再生过程,但这一点并非总能得到认同。实际上,要在肝病的诊断、预后评估和治疗反应需求与良好的成本效益比之间取得平衡非常困难。可能并不需要新的检测方法,而目标应该是更好地利用现有检测方法,以控制不断增加的医疗保健成本。