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[The activity of etoposide (VP16) in combination chemotherapy against human bladder cancer cells in vitro].

作者信息

Hattori T, Satoh M, Terashima Y, Nishimura T, Akimoto M

机构信息

Department of Urology, Nippon Medical School.

出版信息

Hinyokika Kiyo. 1991 Sep;37(9):995-8.

PMID:1785427
Abstract

The activity of Etoposide (VP16) in combination chemotherapy against four human transitional cell carcinoma cell lines of bladder (TCCaB) was determined by in vitro colony formation assay. Four anti-tumor agents (methotrexate: MTX, vinblastine: VBL, adriamycin: ADM, cisplatin: DDP) were used for combination chemotherapy with VP16. The ADM + VP16 combination exhibited a strong synergistic antitumor effect against the human TCCaBs compared with other combinations in this study. The combination chemotherapy of ADM + VP16 may be useful as a new chemotherapeutic regimen for advanced bladder cancer.

摘要

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