Visschers B A J T, Bots R S G M, Peeters M F, Mol B W J, van Dessel H J H M
Department of Obstetrics and Gynaecology, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium.
Reprod Biomed Online. 2007 Sep;15(3):310-5. doi: 10.1016/s1472-6483(10)60344-6.
Cervical mucus may cover the embryo transfer catheter during passage of the cervical canal, interfering with the correct placement of the embryo(s) into the uterine cavity. The effect of removal of cervical mucus prior to embryo transfer in IVF/ intracytoplasmic sperm injection (ICSI) on live birth rate was studied. The study was set up as a single blind randomized controlled trial. Couples undergoing IVF/ICSI were randomly allocated to either removal of cervical mucus prior to embryo transfer, or a mock procedure. Randomization was done with stratification for age, cycle number and method of treatment. Primary outcome was live birth rate. A total of 317 couples were included and underwent 428 cycles, of which the outcome of 3 cycles was unknown. Baseline characteristics of both groups were comparable. Live birth occurred in 52 of 220 (24%) cycles in the treatment group and 42 of 205 (21%) cycles in the control group (risk difference 3%, 95% confidence interval-5- 11%). It is unlikely that removal of cervical mucus prior to embryo transfer has a significant effect on live birth rate. A small effect, however, cannot be excluded.
在胚胎移植导管通过宫颈管的过程中，宫颈黏液可能会覆盖导管，从而干扰胚胎正确放置到子宫腔内。研究了在体外受精/卵胞浆内单精子注射（ICSI）中，胚胎移植前清除宫颈黏液对活产率的影响。该研究设计为单盲随机对照试验。接受体外受精/ICSI的夫妇被随机分配到胚胎移植前清除宫颈黏液组或模拟操作组。随机分组时按年龄、周期数和治疗方法进行分层。主要结局指标为活产率。共纳入317对夫妇，进行了428个周期的治疗，其中3个周期的结局未知。两组的基线特征具有可比性。治疗组220个周期中有52个（24%）实现活产，对照组205个周期中有42个（21%）实现活产（风险差异3%，95%置信区间为-5至11%）。胚胎移植前清除宫颈黏液不太可能对活产率产生显著影响。然而，不能排除有微小影响。
