Chinnusamy Viswanathan, Zhu Jianhua, Zhu Jian-Kang
Water Technology Centre, Indian Agricultural Research Institute, New Delhi, India.
Trends Plant Sci. 2007 Oct;12(10):444-51. doi: 10.1016/j.tplants.2007.07.002. Epub 2007 Sep 12.
Cold stress adversely affects plant growth and development. Most temperate plants acquire freezing tolerance by a process called cold acclimation. Here, we focus on recent progress in transcriptional, post-transcriptional and post-translational regulation of gene expression that is critical for cold acclimation. Transcriptional regulation is mediated by the inducer of C-repeat binding factor (CBF) expression 1 (ICE1), the CBF transcriptional cascade and CBF-independent regulons during cold acclimation. ICE1 is negatively regulated by ubiquitination-mediated proteolysis and positively regulated by SUMO (small ubiquitin-related modifier) E3 ligase-catalyzed sumoylation. Post-transcriptional regulatory mechanisms, such as pre-mRNA splicing, mRNA export and small RNA-directed mRNA degradation, also play important roles in cold stress responses.
冷胁迫对植物的生长发育产生不利影响。大多数温带植物通过一种称为冷驯化的过程获得抗冻能力。在此，我们关注基因表达在转录、转录后和翻译后水平调控方面的最新进展，这些调控对于冷驯化至关重要。在冷驯化过程中，转录调控由C-重复结合因子（CBF）表达诱导因子1（ICE1）、CBF转录级联反应以及不依赖CBF的调控子介导。ICE1受到泛素化介导的蛋白水解的负调控，并受到小泛素相关修饰物（SUMO）E3连接酶催化的SUMO化的正调控。转录后调控机制，如前体mRNA剪接、mRNA输出和小RNA介导的mRNA降解，在冷胁迫响应中也发挥着重要作用。
