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IFN-α exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infection.干扰素-α 对激活诱导的和白细胞介素-7 诱导的 T 细胞增殖具有相反的作用，这可能会损害接受治疗的 HIV 感染患者中 CD4+ T 细胞数量的稳态维持。
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Responsiveness to IL-7 but not to IFN-α is diminished in CD4+ T cells from treated HIV infected patients who experience poor CD4+ T-cell recovery.在接受治疗但CD4+ T细胞恢复不佳的HIV感染患者的CD4+ T细胞中，对白细胞介素-7（IL-7）而非干扰素-α（IFN-α）的反应性降低。
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Despite an impaired response to IL-7, CD4+EM T cells from HIV-positive patients proliferate normally in response to IL-15 and its superagonist, RLI.尽管对白细胞介素 7（IL-7）的反应受损，但来自 HIV 阳性患者的 CD4+EM T 细胞对白细胞介素 15（IL-15）及其超级激动剂 RLI 的增殖反应正常。
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Interleukin-7 signalling defects in naive CD4+ T cells of HIV patients with CD4+ T-cell deficiency on antiretroviral therapy are associated with T-cell activation and senescence.接受抗逆转录病毒治疗但存在CD4+T细胞缺陷的HIV患者，其初始CD4+T细胞中的白细胞介素-7信号缺陷与T细胞活化和衰老相关。
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Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapy.HIV感染中白细胞介素-7受体（CD127）的下调与T细胞活化相关，并且是影响抗逆转录病毒治疗后CD4(+)细胞恢复的主要因素。
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Residual immune dysregulation syndrome in treated HIV infection.治疗后 HIV 感染的残余免疫失调综合征。
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Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway.人类免疫缺陷病毒感染中白细胞介素-7（IL-7）反应受损的双重机制：IL-7 结合减少和 JAK/STAT5 途径的异常激活。
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Interleukin-7 receptor signaling is deficient in CD4+ T cells from HIV-infected persons and is inversely associated with aging.白细胞介素-7受体信号传导在HIV感染者的CD4+ T细胞中存在缺陷，且与衰老呈负相关。
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本文引用的文献

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Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation.巨细胞病毒特异性CD4 + T淋巴细胞随着细胞成熟获得直接抗病毒效应功能。
J Exp Med. 2006 Dec 25;203(13):2865-77. doi: 10.1084/jem.20052246. Epub 2006 Dec 11.
2
The correlation between levels of IL-7Ralpha expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients.在HIV感染患者的CD4淋巴细胞中，IL-7Rα表达水平与对IL-7的反应性之间的相关性丧失。
AIDS. 2007 Jan 2;21(1):101-3. doi: 10.1097/QAD.0b013e3280115b6a.
3
CD127 expression and regulation are altered in the memory CD8 T cells of HIV-infected patients--reversal by highly active anti-retroviral therapy (HAART).HIV感染患者记忆性CD8 T细胞中CD127的表达及调控发生改变——高效抗逆转录病毒疗法（HAART）可使其逆转
Clin Exp Immunol. 2006 Mar;143(3):398-403. doi: 10.1111/j.1365-2249.2006.03022.x.
4
IL-7Ralpha expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation.CD4+ T淋巴细胞上的白细胞介素-7受体α（IL-7Rα）表达随着HIV疾病进展而降低，且与免疫激活呈负相关。
Eur J Immunol. 2006 Feb;36(2):336-44. doi: 10.1002/eji.200535111.
5
Loss of IL-7Ralpha is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients.白细胞介素-7受体α的缺失与HIV感染患者的CD4 T细胞耗竭、白细胞介素-7水平升高及CD28下调有关。
AIDS. 2005 Dec 2;19(18):2077-86. doi: 10.1097/01.aids.0000189848.75699.0f.
6
Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool.辅助性白细胞介素-7或白细胞介素-15可克服免疫显性并改善CD8 +记忆细胞库的存活。
J Clin Invest. 2005 May;115(5):1177-87. doi: 10.1172/JCI23134. Epub 2005 Apr 7.
7
Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals.CD127表达缺失定义了HIV感染个体中效应性CD8 + T细胞的扩增。
J Immunol. 2005 Mar 1;174(5):2900-9. doi: 10.4049/jimmunol.174.5.2900.
8
Circulating levels of IL-7 but not IL-15, IGF-1, and TGF-beta are elevated during primary HIV-1 infection.在原发性HIV-1感染期间，循环中的白细胞介素-7水平升高，而白细胞介素-15、胰岛素样生长因子-1和转化生长因子-β水平未升高。
HIV Clin Trials. 2004 Sep-Oct;5(5):357-9. doi: 10.1310/M0CV-R6BX-A9DP-JJV0.
9
Recombinant interleukin-7 induces proliferation of naive macaque CD4+ and CD8+ T cells in vivo.重组白细胞介素-7在体内诱导猕猴幼稚CD4+和CD8+ T细胞增殖。
J Virol. 2004 Sep;78(18):9740-9. doi: 10.1128/JVI.78.18.9740-9749.2004.
10
A role for TCR affinity in regulating naive T cell homeostasis.TCR亲和力在调节初始T细胞稳态中的作用。
J Immunol. 2004 Jan 1;172(1):40-4. doi: 10.4049/jimmunol.172.1.40.

白细胞介素-7增强了来自人类免疫缺陷病毒感染者的初始CD4 + T细胞对T细胞受体刺激的增殖反应。

Interleukin-7 enhances proliferation responses to T-cell receptor stimulation in naïve CD4+ T cells from human immunodeficiency virus-infected persons.

作者信息

Bazdar Douglas A, Sieg Scott F

机构信息

Department of Medicine, Division of Infectious Diseases, Center for AIDS Research, Case Western Reserve University, Cleveland, OH 44106, USA.

出版信息

J Virol. 2007 Nov;81(22):12670-4. doi: 10.1128/JVI.00476-07. Epub 2007 Sep 12.

DOI:10.1128/JVI.00476-07
PMID:17855550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2169009/
Abstract

Proliferation responses of naïve CD4(+) T cells to T-cell receptor and interleukin-7 (IL-7) stimulation were evaluated by using cells from human immunodeficiency virus-positive (HIV(+)) donors. IL-7 enhanced responses to T-cell receptor stimulation, and the magnitude of this enhancement was similar in cells from healthy controls and from HIV(+) subjects. The overall response to T-cell receptor stimulation alone or in combination with IL-7, however, was diminished among viremic HIV(+) donors and occurred independent of antigen-presenting cells. Frequencies of CD127(+) cells were related to the magnitudes of proliferation enhancement that were mediated by IL-7. Thus, IL-7 enhances but does not fully restore the function of naïve CD4(+) T cells from HIV-infected persons.

摘要

通过使用来自人类免疫缺陷病毒阳性（HIV(+)）供体的细胞，评估了初始CD4(+) T细胞对T细胞受体和白细胞介素-7（IL-7）刺激的增殖反应。IL-7增强了对T细胞受体刺激的反应，并且这种增强的程度在来自健康对照和HIV(+)受试者的细胞中相似。然而，在病毒血症HIV(+)供体中，单独或与IL-7联合对T细胞受体刺激的总体反应减弱，并且该反应独立于抗原呈递细胞发生。CD127(+)细胞的频率与IL-7介导的增殖增强幅度相关。因此，IL-7增强但不能完全恢复HIV感染者初始CD4(+) T细胞的功能。