白细胞介素-7增强了来自人类免疫缺陷病毒感染者的初始CD4 + T细胞对T细胞受体刺激的增殖反应。
Interleukin-7 enhances proliferation responses to T-cell receptor stimulation in naïve CD4+ T cells from human immunodeficiency virus-infected persons.
作者信息
Bazdar Douglas A, Sieg Scott F
机构信息
Department of Medicine, Division of Infectious Diseases, Center for AIDS Research, Case Western Reserve University, Cleveland, OH 44106, USA.
出版信息
J Virol. 2007 Nov;81(22):12670-4. doi: 10.1128/JVI.00476-07. Epub 2007 Sep 12.
Abstract
Proliferation responses of naïve CD4(+) T cells to T-cell receptor and interleukin-7 (IL-7) stimulation were evaluated by using cells from human immunodeficiency virus-positive (HIV(+)) donors. IL-7 enhanced responses to T-cell receptor stimulation, and the magnitude of this enhancement was similar in cells from healthy controls and from HIV(+) subjects. The overall response to T-cell receptor stimulation alone or in combination with IL-7, however, was diminished among viremic HIV(+) donors and occurred independent of antigen-presenting cells. Frequencies of CD127(+) cells were related to the magnitudes of proliferation enhancement that were mediated by IL-7. Thus, IL-7 enhances but does not fully restore the function of naïve CD4(+) T cells from HIV-infected persons.
摘要
通过使用来自人类免疫缺陷病毒阳性（HIV(+)）供体的细胞，评估了初始CD4(+) T细胞对T细胞受体和白细胞介素-7（IL-7）刺激的增殖反应。IL-7增强了对T细胞受体刺激的反应，并且这种增强的程度在来自健康对照和HIV(+)受试者的细胞中相似。然而，在病毒血症HIV(+)供体中，单独或与IL-7联合对T细胞受体刺激的总体反应减弱，并且该反应独立于抗原呈递细胞发生。CD127(+)细胞的频率与IL-7介导的增殖增强幅度相关。因此，IL-7增强但不能完全恢复HIV感染者初始CD4(+) T细胞的功能。
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