Jackson Andrew, Fetz Eberhard E
School of Neurology, Neurobiology and Psychiatry, University of Newcastle, Newcastle-upon-Tyne, United Kingdom.
J Neurophysiol. 2007 Nov;98(5):3109-18. doi: 10.1152/jn.00569.2007. Epub 2007 Sep 12.
We describe a small, chronically implantable microwire array for obtaining long-term unit recordings from the cortex of unrestrained nonhuman primates. After implantation, the depth of microwires can be individually adjusted to maintain large-amplitude action potential recordings from single neurons over many months. We present data recorded from the primary motor cortex of two monkeys by autonomous on-board electronic circuitry. Waveforms of individual neurons remained stable for recording periods of several weeks during unrestrained behavior. Signal-to-noise ratios, waveform stability, and rates of cell loss indicate that this method may be particularly suited to experiments investigating the neural correlates of processes extending over multiple days, such as learning and plasticity.
我们描述了一种小型的、可长期植入的微丝阵列，用于从不受约束的非人灵长类动物的皮质获取长期的单位记录。植入后，微丝的深度可单独调整，以在数月内维持对单个神经元的大振幅动作电位记录。我们展示了由自主车载电子电路从两只猴子的初级运动皮质记录的数据。在不受约束的行为期间，单个神经元的波形在数周的记录期内保持稳定。信噪比、波形稳定性和细胞丢失率表明，这种方法可能特别适合研究跨越数天的过程（如学习和可塑性）的神经相关性的实验。
