Jobin M, Delgado A, Fortier C
Horm Res. 1975;6(4):199-212. doi: 10.1159/000178694.
In intact rats acclimated to 25 +/- 1 degrees C, acute exposure to cold resulted in simultaneous stimulation of TSH and ACTH secretion. The plasma TSH response to cold was identical at temperatures varying from +14 to -10 degrees C, whereas the adrenocortical response increased proportionally to the severity of cold. Acute stimulation of ACTH secretion by exposure to a stressful situation (electrical shocks) did not alter the TSH response to cold. Conversely, acute blockade of the pituitary-adrenocortical response by dexamethasone treatment did not enhance the TSH response to cold. Chronic stimulation of ACTH secretion resulting from adrenalectomy did not interfere with the TSH response during subsequent exposure to cold. However, a reduced adrenocortical response to cold was observed during chronic hypersecretion of TSH resulting from previous thyroidectomy. These findings do not support the hypothesis of an inverse relationship between TSH and ACTH secretions during acute cold exposure, but rather suggest that these secretions are independent.
在适应于25±1℃的成年大鼠中，急性冷暴露会导致促甲状腺激素（TSH）和促肾上腺皮质激素（ACTH）分泌同时受到刺激。在温度从+14℃变化到-10℃时，血浆TSH对寒冷的反应是相同的，而肾上腺皮质反应则与寒冷的严重程度成比例增加。通过暴露于应激情况（电击）对ACTH分泌进行急性刺激，并不会改变TSH对寒冷的反应。相反，地塞米松治疗对垂体-肾上腺皮质反应进行急性阻断，并不会增强TSH对寒冷的反应。肾上腺切除导致的ACTH分泌慢性刺激，在随后的冷暴露过程中并不会干扰TSH反应。然而，在先前甲状腺切除导致的TSH慢性分泌过多期间，观察到肾上腺皮质对寒冷的反应减弱。这些发现并不支持急性冷暴露期间TSH和ACTH分泌呈负相关的假说，而是表明这些分泌是独立的。
