利血平对大鼠下丘脑-垂体-肾上腺皮质功能的影响。
The effect of reserpine on hypothalamo-pituitary-adrenocortical function in the rat.
作者信息
Hodges J R, Vellucci S V
出版信息
Br J Pharmacol. 1975 Apr;53(4):555-61. doi: 10.1111/j.1476-5381.1975.tb07394.x.
Abstract
- The effect of reserpine on hypothalamo-pituitary-adrenocortical (HPA) function in the rat was investigated by the use of direct and indirect indices of pituitary adrenocorticotrophic activity. 2. Administration of a single dose of the drug induced prolonged hypersecretion of corticotrophin (ACTH). 3. Corticotrophin release in response to the drug no longer occurred after repeated daily injections, indicating that some form of 'adaptation' occurred. 4. The increase in HPA activity normally caused by exposure to cold was prevented by reserpine once 'adaptation' to the drug had been produced. 5. Inhibition of stress-induced ACTH release was due neither to depletion of pituitary stores of the hormone, nor to a corticosteroid feedback effect.
摘要
- 通过使用垂体促肾上腺皮质激素活性的直接和间接指标，研究了利血平对大鼠下丘脑 - 垂体 - 肾上腺皮质（HPA）功能的影响。2. 单次给药该药物可诱导促肾上腺皮质激素（ACTH）长期分泌过多。3. 每日重复注射后，对该药物的促肾上腺皮质激素释放不再发生，表明发生了某种形式的“适应”。4. 一旦对该药物产生“适应”，利血平可阻止因暴露于寒冷而正常引起的HPA活性增加。5. 应激诱导的ACTH释放的抑制既不是由于垂体激素储备的耗尽，也不是由于皮质类固醇的反馈作用。
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本文引用的文献
1
Effects of single and repeated doses of reserpine on the secretion of adrenocorticotrophic hormone.利血平单次及重复给药对促肾上腺皮质激素分泌的影响。
Br J Pharmacol Chemother. 1962 Apr;18(2):337-45. doi: 10.1111/j.1476-5381.1962.tb01414.x.
2
Effects of reserpine and cold-exposure on pituitary-adrenocortical function in rats.利血平和冷暴露对大鼠垂体-肾上腺皮质功能的影响。
J Pharmacol Exp Ther. 1961 Nov;134:167-75.
3
Depletion of pituitary corticotrophin by reserpine and by a nitrogen mustard.利血平和氮芥对垂体促肾上腺皮质激素的耗竭作用。
Br J Pharmacol Chemother. 1960 Mar;15(1):165-9. doi: 10.1111/j.1476-5381.1960.tb01226.x.
4
"Inhibition" of pituitary ACTH release after administration of reserpine or epinephrine.给予利血平或肾上腺素后垂体促肾上腺皮质激素释放的“抑制”
Endocrinology. 1959 Oct;65:548-54. doi: 10.1210/endo-65-4-548.
5
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J Physiol. 1964 Sep;173(2):190-200. doi: 10.1113/jphysiol.1964.sp007451.
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