Duncan W K, Perkins T M, O Carroll M K, Hill W J
Department of Pediatric Dentistry, University of Mississippi School of Dentistry.
Ann Dent. 1991 Winter;50(2):18-21.
Dentin dysplasia is a rare developmental disturbance of dentin affecting approximately 1:100,000 people. It has been classified as an autosomal dominant disease. Two distinct forms of dentin dysplasia have been described. As more cases of dentin dysplasia were reported these categories seemed inadequate; subclassification of type I dentin dysplasia were proposed based on root length and the presence or not of a pulpal remnant. This paper presents two cases demonstrating the classic features of type I dentin dysplasia in the mixed and permanent dentitions and discusses the suggested subclassifications. The authors suggest that while differences in root length may be useful in determining treatment options, thinking of these variables as separate types of dentin dysplasia is not warranted at this time. Justification of a subcategory of type I dentin dysplasia should be based on a different disease process, different histology, significantly different symptoms, or different etiologies, and until researchers can clearly prove from a genetic or chromosomal standpoint that the subcategories are separate entities, we should accept, as we do for many other genetic disorders, that some patients are more severely affected than others.
牙本质发育异常是一种罕见的牙本质发育障碍疾病，发病率约为1:100,000。它被归类为常染色体显性疾病。目前已描述了两种不同类型的牙本质发育异常。随着更多牙本质发育异常病例的报道，这些分类似乎并不完善；基于牙根长度以及牙髓残留情况，对I型牙本质发育异常进行了进一步的分类。本文报告了两例病例，展示了混合牙列和恒牙列中I型牙本质发育异常的典型特征，并讨论了建议的分类。作者认为，虽然牙根长度的差异可能有助于确定治疗方案，但目前将这些变量视为不同类型的牙本质发育异常是不合理的。I型牙本质发育异常亚类的划分应基于不同的疾病过程、不同的组织学、显著不同的症状或不同的病因，在研究人员能够从基因或染色体角度明确证明这些亚类是独立的实体之前，我们应该像对待许多其他遗传疾病一样接受，即有些患者的病情比其他患者更严重。
