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肉鸡慢性暴露后硼酸的急性毒性及硼组织残留

Acute toxicity of boric acid and boron tissue residues after chronic exposure in broiler chickens.

作者信息

Sander J E, Dufour L, Wyatt R D, Bush P B, Page R K

机构信息

Cooperative Extension Service, University of Georgia, Athens 30602.

出版信息

Avian Dis. 1991 Oct-Dec;35(4):745-9.

PMID:1786007
Abstract

The acute oral mean lethal dose of boric acid in 1-day-old chickens was found to be 2.95 +/- 0.35 g/kg of body weight, which classifies this product as only slightly toxic to chickens. One-day-old broiler chicks were housed in floor pens in which litter had been treated with 0, 0.9, 3.6, or 7.2 kg of boric acid per 9.9 m2 of floor space. Boron residue levels in brain, kidney, liver, and white muscle were not statistically elevated following a 15-day exposure period. Boron residue levels in the same types of tissue were not significantly elevated in chicks fed 500 ppm or 1250 ppm boric acid in feed ad libitum for 3 weeks; however, residues were significantly higher in chicks fed 2500 ppm or 5000 ppm boric acid. These data indicate that broilers grown on boric acid-treated litter do not consume enough boric acid to cause elevated boron levels in tissues.

摘要

1日龄雏鸡经口摄入硼酸的急性平均致死剂量为2.95±0.35克/千克体重,据此该产品对雏鸡仅具轻微毒性。1日龄肉仔鸡饲养在地面平养栏舍中,栏舍地面每9.9平方米垫料分别用0、0.9、3.6或7.2千克硼酸处理。在15天的暴露期后,脑、肾、肝和白肌中的硼残留水平无统计学意义的升高。随意采食含500 ppm或1250 ppm硼酸饲料3周的雏鸡,相同组织类型中的硼残留水平也无显著升高;然而,采食2500 ppm或5000 ppm硼酸的雏鸡,其残留量显著更高。这些数据表明,在经硼酸处理垫料上生长的肉仔鸡摄入的硼酸不足以导致组织中硼水平升高。

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