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Expression of perforin and granzymes in vivo: potential diagnostic markers for activated cytotoxic cells.

作者信息

Griffiths G M, Mueller C

机构信息

Basel Institute for Immunology, Switzerland.

出版信息

Immunol Today. 1991 Nov;12(11):415-9. doi: 10.1016/0167-5699(91)90145-J.

DOI:10.1016/0167-5699(91)90145-J
PMID:1786074
Abstract

Perforin and granzymes are considered to be instrumental in cell-mediated cytolysis by cytotoxic T cells and natural killer cells. Here, Gillian Griffiths and Christoph Mueller describe the expression of perforin and granzymes, emphasizing studies in vivo, and discuss the possibility that these proteins are useful diagnostic markers for immune responses involving cytolytic cells.

摘要

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