Galderisi S, Mucci A, Mignone M L, Maj M, Kemali D
Department of Psychiatry, First Medical School, University of Naples, Italy.
Schizophr Res. 1991 Dec;6(1):15-23. doi: 10.1016/0920-9964(91)90016-k.
A topographic CEEG investigation was carried out in 20 drug-free, DSM-IIIR diagnosed schizophrenics and in a group of matched healthy controls. The effects of acute and chronic haloperidol treatment were then assessed in the patient group. On the baseline recording, schizophrenics showed a widespread increase in delta, theta 1 and beta 3 amplitude. Acute haloperidol administration produced a decrease in delta and an increase in slow beta amplitude. After 28 days of treatment, delta and fast beta were reduced while theta 2 and alpha 1 were increased. CEEG abnormalities in schizophrenic subjects appear, therefore, to be reduced by chronic neuroleptic treatment.
对20名未服用药物、经《精神疾病诊断与统计手册》第三版修订本（DSM-IIIR）诊断为精神分裂症的患者以及一组匹配的健康对照者进行了脑电地形图（CEEG）研究。然后评估了患者组中急性和慢性氟哌啶醇治疗的效果。在基线记录时，精神分裂症患者的δ波、θ1波和β3波振幅普遍增加。急性给予氟哌啶醇使δ波减少，慢β波振幅增加。治疗28天后，δ波和快β波减少，而θ2波和α1波增加。因此，慢性抗精神病药物治疗似乎可减轻精神分裂症患者的CEEG异常。
