Scott J J
Department of Physiology, University of Leicester, U.K.
Brain Res. 1991 Nov 1;563(1-2):195-202. doi: 10.1016/0006-8993(91)91533-7.
Nerve regeneration promoters offer the possibility of enhancing recovery following nerve injury by increasing the numbers of regenerating axons and decreasing the period of tissue denervation. To date, recent studies have concentrated on evaluating the action of such promoters on the nerve itself and on the restoration of motor function. This study examines afferent regeneration by evaluating the recovery of muscle spindles and tendon organs after nerve injury and treatment with alpha-melanocyte stimulating hormone or nerve stimulation. Treatment was found to be effective in enhancing short-term recovery after nerve-crush injury in terms of increasing the rate of functional and morphological recovery. Following nerve section, there was an increase in the number of reinnervating axons compared with control values.
神经再生促进剂为通过增加再生轴突数量和缩短组织去神经支配时间来促进神经损伤后恢复提供了可能性。迄今为止，近期研究主要集中于评估此类促进剂对神经本身的作用以及运动功能的恢复情况。本研究通过评估神经损伤后以及用α-黑素细胞刺激素或神经刺激治疗后肌梭和腱器官的恢复情况来检测传入神经再生。结果发现，就提高功能和形态恢复率而言，该治疗在促进神经挤压伤后的短期恢复方面是有效的。与对照值相比，神经切断后再支配轴突的数量有所增加。
