Quock R M, Vaughn L K
Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford 61107.
Brain Res Bull. 1991 Dec;27(6):857-9. doi: 10.1016/0361-9230(91)90223-7.
Apomorphine produced a greater hypothermic response in spontaneously hypertensive rats (SHRs) than in normotensive Wistar-Kyoto rats (WKYs). Experiments were conducted in SHRs and WKYs of three age groups to determine whether the increased hypothermic responsiveness to apomorphine occurs prior to the development of hypertension. The mean systolic blood pressures (SBPs) of SHRs and WKYs were comparable at 4-6 weeks of age. The mean SBP of SHRs were significantly greater than that of WKYs at both 8-10 and 12-15 weeks of age. Yet SHRs responded to apomorphine with significantly greater hypothermia than WKYs at all three ages. These findings indicate that the hyperresponsiveness of SHRs to apomorphine-induced hypothermia precedes the development of hypertension. This sequence of events is consistent with the hypothesis that central DA systems play a role in development of hypertension in SHRs.
阿扑吗啡对自发性高血压大鼠（SHR）产生的体温过低反应比对正常血压的Wistar - Kyoto大鼠（WKY）更强烈。对三个年龄组的SHR和WKY进行了实验，以确定对阿扑吗啡体温过低反应性增加是否在高血压发展之前出现。SHR和WKY在4 - 6周龄时平均收缩压（SBP）相当。在8 - 10周龄和12 - 15周龄时，SHR的平均SBP均显著高于WKY。然而，在所有三个年龄组中，SHR对阿扑吗啡的体温过低反应均显著大于WKY。这些发现表明，SHR对阿扑吗啡诱导的体温过低的高反应性先于高血压的发展。这一系列事件与中枢多巴胺系统在SHR高血压发展中起作用的假设一致。
