Reza A S, Zaher A, Reza A Q M, Ali M
Deptt. of Cardiology, National Institute of Cardiovascular Diseases (NICVD), Sher-e-Banglanagar, Dhaka, Bangladesh.
Bangladesh Med Res Counc Bull. 2006 Dec;32(3):78-86.
Microalbuminuria has emerged as an important risk factor of considerable prognostic importance for cardiovascular events. Little is known about its impact on the angiographic profile among coronary artery disease patients. The primary aim of the study was to investigate the relationship of microalbuminuria and angiographic severity of coronary artery disease. This was a cross-sectional study conducted in NICVD, a tertiary-care cardiac center in Dhaka, Bangladesh. For this purpose, 72 patients aged 25 to 70 years, who underwent elective coronary angiogram were studied. Urinary albumin to creatinine ratio was used as a measure of microalbuminuria. Angiographic severity of coronary artery disease was measured by number of major vessels involved (vessel score), stenosis score, extent score and number of type B and C lesions. All parameters of angiographic severity were significantly higher in microalbuminuric patients. Spearman's rank correlation coefficient showed significant positive correlation between albumin to creatinine ratio and different parameters of angiographic severity. In multivariate logistic regression analysis odds ratio of having triple vessel coronary artery disease in microalbuminuric patients was 5.6 (95% CI, 1.4 - 22). Microalbuminuria was found to correlate positively and independently with angiographic severity of coronary artery disease.
微量白蛋白尿已成为心血管事件中具有重要预后意义的重要危险因素。关于其对冠心病患者血管造影特征的影响，人们了解甚少。本研究的主要目的是探讨微量白蛋白尿与冠心病血管造影严重程度之间的关系。这是一项在孟加拉国达卡的三级心脏护理中心NICVD进行的横断面研究。为此，研究了72例年龄在25至70岁之间接受择期冠状动脉造影的患者。尿白蛋白与肌酐比值用作微量白蛋白尿的衡量指标。冠心病的血管造影严重程度通过受累主要血管数量（血管评分）、狭窄评分、范围评分以及B型和C型病变数量来衡量。微量白蛋白尿患者的所有血管造影严重程度参数均显著更高。Spearman等级相关系数显示白蛋白与肌酐比值与血管造影严重程度的不同参数之间存在显著正相关。在多变量逻辑回归分析中，微量白蛋白尿患者患三支血管冠心病的优势比为5.6（95%CI，1.4 - 22）。研究发现微量白蛋白尿与冠心病的血管造影严重程度呈正相关且独立相关。
